치매 환자에서 기능 영상법의 역할 (The Role of Functional Imaging Techniques in the Dementia South Korea.) |
Author |
유영훈, |
Young Hoon Ryu, M.D. |
Affiliation |
연세대학교 의과대학 진단방사선과학교실 핵의학과 Division of Nuclear Medicine, Department of Diagnostic Radiology, College of Medicine, Yonsei University, |
Abstract |
Evaluation of dementia in patients with early symptoms of cognitive decline is clinically challenging, but the need
for early, accurate diagnosis has become more crucial, since several medication for the treatment of mild to
moderate Alzheimer’ disease are available. Many neurodegenerative diseases produce significant brain function
alteration even when structural imaging (CT or MRI) reveal no specific abnormalities. The role of PET and SPECT
brain imaging in the initial assessment and differential diagnosis of dementia is beginning to evolve rapidly and
growing evidence indicates that appropriate incorporation of PET into the clinical work‐up can improve
diagnostic and prognostic accuracy with respect to Alzheimer’s disease, the most common cause of dementia in
the geriatric population. In the fast few years, studies comparing neuropathologic examination with PET have
established reliable and consistent accuracy for diagnostic evaluations using PET – accuracies substantially
exceeding those of comparable studies of diagnostic value of SPECT or of both modalities assessed side by side,
or of clinical evaluations done without nuclear imaging. This review deals the role of functional brain imaging
techniques in the evaluation of dementias and the role of nuclear neuroimaging in the early detection and
diagnosis of Alzheimer’s disease. (Korean J Nucl Med 38(3):209-217, 2004) |
Keyword |
Dementia, Alzheimer’s disease, PET, FDG, functional brain imaging, SPECT, MRI, MRS |
Full text Article |
3803209.pdf
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