대한핵의학회지 (1967년~2009년)
대한핵의학회지 2004;38(3)209~217
치매 환자에서 기능 영상법의 역할
(The Role of Functional Imaging Techniques in the Dementia South Korea.)
Author 유영훈,
Young Hoon Ryu, M.D.
Affiliation 연세대학교 의과대학 진단방사선과학교실 핵의학과
Division of Nuclear Medicine, Department of Diagnostic Radiology, College of Medicine, Yonsei University,
Abstract

Evaluation of dementia in patients with early symptoms of cognitive decline is clinically challenging, but the need for early, accurate diagnosis has become more crucial, since several medication for the treatment of mild to moderate Alzheimer’ disease are available. Many neurodegenerative diseases produce significant brain function alteration even when structural imaging (CT or MRI) reveal no specific abnormalities. The role of PET and SPECT brain imaging in the initial assessment and differential diagnosis of dementia is beginning to evolve rapidly and growing evidence indicates that appropriate incorporation of PET into the clinical work‐up can improve diagnostic and prognostic accuracy with respect to Alzheimer’s disease, the most common cause of dementia in the geriatric population. In the fast few years, studies comparing neuropathologic examination with PET have established reliable and consistent accuracy for diagnostic evaluations using PET – accuracies substantially exceeding those of comparable studies of diagnostic value of SPECT or of both modalities assessed side by side, or of clinical evaluations done without nuclear imaging. This review deals the role of functional brain imaging techniques in the evaluation of dementias and the role of nuclear neuroimaging in the early detection and diagnosis of Alzheimer’s disease. (Korean J Nucl Med 38(3):209-217, 2004)

Keyword Dementia, Alzheimer’s disease, PET, FDG, functional brain imaging, SPECT, MRI, MRS
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