두층 섬광결정과 위치민감형광전자증배관을 이용한 소동물 양전자방출단층촬영기 개발: 기초실험 결과 (Development of a Small Animal Positron Emission Tomography Using Dual-Layer Phoswich Detector and Position Sensitive Photomultiplier Tube: Preliminary Results) |
Author |
정명환*.최 용*.정용현*.송태용*.정진호*.홍기조*.민병준*.최연성.이경한.김병태, |
Myung Hwan Jeong*, Yong Choi*, Ph.D., Yong Hyun Chung*, M.S., Tae Yong Song*, M.S., Jin Ho Jung*, M.S., Key Jo Hong*, Byung Jun Min*, Yearn Seong Choe, Ph.D., Kyung-Han Lee, M.D. and Byung-Tae Kim, M.D. |
Affiliation |
성균관대학교 의과대학 생명의공학과, 삼성서울병원 핵의학과, Crystal Clear Collaboration* Departments of Biomedical Engineering and Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Member of Crystal Clear Collaboration* |
Abstract |
Purpose: The purpose of this study was to develop a small animal PET using dual layer phoswich detector to
minimize parallax error that degrades spatial resolution at the outer part of field-of-view (FOV). Materials and
Methods: A simulation tool GATE (Geant4 Application for Tomographic Emission) was used to derive optimal
parameters of small PET, and PET was developed employing the parameters. Lutetium Oxyorthosilicate (LSO) and
Lutetium-Yttrium Aluminate-Perovskite (LuYAP) was used to construct dual layer phoswitch crystal. 8 × 8 arrays
of LSO and LuYAP pixels, 2 mm × 2 mm × 8 mm in size, were coupled to a 64-channel position sensitive
photomultiplier tube. The system consisted of 16 detector modules arranged to one ring configuration (ring inner
diameter 10 cm, FOV of 8 cm). The data from phoswich detector modules were fed into an ADC board in the
data acquisition and preprocessing PC via sockets, decoder block, FPGA board, and bus board. These were linked
to the master PC that stored the events data on hard disk. Results: In a preliminary test of the system,
reconstructed images were obtained by using a pair of detectors and sensitivity and spatial resolution were
measured. Spatial resolution was 2.3 mm FWHM and sensitivity was 10.9 cps/μCi at the center of FOV.
Conclusion: The radioactivity distribution patterns were accurately represented in sinograms and images obtained
by PET with a pair of detectors. These preliminary results indicate that it is promising to develop a high
performance small animal PET. (Korean J Nucl Med 38(5):338-343, 2004) |
Keyword |
Animal PET, Phoswich detector, Depth of interaction |
Full text Article |
380502.pdf
|
|
|