류마티스 관절염환자에서 Tc-99m MIBI 영상의 유용성 평가 (Evaluation of Patients with Rheumatoid Arthritis by Tc-99m MIBI Imaging) |
Author |
조인호1, 천경아1, 홍영훈2, 이충기2, 하정희3, |
Ihn Ho Cho, M.D.1, Kyung Ah Chun, M.D.1, Young Hoon Hong, M.D.2, Choong Ki Lee, M.D.2,Jeung-Hee Ha, M.D.3 |
Affiliation |
영남대학교병원 핵의학과1, 감염.류마티스 내과2, 경북대학교 의과대학 약리학교실3 Department of Nuclear Medicine1, Department of Rheumatology2, Yeungnam University Hospitall, Departmentof Pharmacology3, KyungPook National University School of Medicine |
Abstract |
Purpose: We investigated whether Tc-99m MIBI imaging is useful to predict the response of drug treatment in
patients with rheumatoid arthritis. Materials and Methods: 24 patients (15 women and 9 men, age 49¡¾12 year)
rheumatoid arthritis and treated with disease modifying antirheumatic drugs (DMARDs) were included in this study.
Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured, and Tc-99m MIBI scan was
obtained before drug treatment. Quantitative analysis of uptake in diseased joints was performed and expressed as
joint-to background ratio (J/B) and percent retention (%R) of Tc-99m MIBI. Clinical symptoms were evaluated and
graded from 0 (no) to 3 (severe) regarding to presence of tenderness and swelling. Results: J/B of the diseased
joints were significantly correlated with ESR and CRP (p<0.05). A highly significant correlation was found between
the improvement of clinical symptoms and %R of Tc-99m MIBI (p<0.05). Conclusion: The results demonstrate that
Tc-99m MIBI scan may be used to predict the therapeutic response in patients with rheumatoid arthritis.(Korean J
Nucl Med 38(6):506-510, 2004) |
Keyword |
Rheumatoid arthritis; Tc-99m MIBI, DMARDs |
Full text Article |
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