마이크로 PET을 이용한 고양이 뇌 경색 모델의 평가 (Evaluation of Cat Brain Infarction Model Using MicroPET) |
Author |
이종진, 이동수, 김윤희, 황도원, 김진수, 임상무1, 정준기, 이명철, |
Jong Jin Lee, M.D., Dong Soo Lee, M.D., Yun Hui Kim, M.S., Do Won Hwang, B.S., Jin Su Kim, M.S.,Sang Moo Lim, M.D., June-Key Chung, M.D., Myung Chul Lee, M.D. |
Affiliation |
서울대학교 의과대학 핵의학교실, 원자력 의학원 핵의학과1 Departments of Nuclear Medicine, Seoul National University College of Medicine; Departments of Nuclear Medicine,Korea Institute of Radiological and Medical Sciences1, Seoul, Korea. |
Abstract |
Purpose: PET has some disadvantage in the imaging of small animal due to poor resolution. With the advent of
microPET scanner, it is possible to image small animals. However, the image quality was not good enough as
human image. Due to larger brain, cat brain imaging was superior to mouse or rat. In this study, we established
the cat brain infarction model and evaluate it and its temporal change using microPET scanner. Materials and
Methods: Two adult male cats were used. Anesthesia was done with xylazine and ketamine HCl. A burr hole was
made at 1cm right lateral to the bregma. Collagenase type IV 10 ㎕was injected using 30 G needle for 5
minutes to establish the infarction model. 18F-FDG microPET (Concorde Microsystems Inc., Knoxville, TN) scans were
performed 1, 11 and 32 days after the infarction. In addition, 18F-FDG PET scans were performed using human PET
scanner (Gemini, Philips medical systems, CA, USA) 13 and 47 days after the infarction. Results: Two cat brain
infarction models were established. The glucose metabolism of an infarction lesion improved with time. An
infarction lesion was also distinguishable in the human PET scan. Conclusion: We successfully established the cat
brain infarction model and evaluated the infarcted lesion and its temporal change using 18F-FDG microPET scanner.
(Korean J Nucl Med 38(6):528-531, 2004) |
Keyword |
Cat, brain infarction, microPET |
Full text Article |
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