골친화성 방사성의약품 153Sm-EDTMP의 합성과 동물영상 (Preparation and Animal Imaging of 153Sm-EDTMP as a Bone Seeking Radiopharmaceutical) |
Author |
최태현1.김세중3.신병철3.우광선1.정위섭1.최창운1,2.임상무1,2, |
Tae Hyun Choi, Ph.D.1, Se Jung Kim, M.S.3, Byung-Chul Shin, Ph.D.3, Kwang Sun Woo, M.T.1, Wee Sup Chung, M.T.1, Chang Woon Choi, M.D., Ph.D.1,3, Sang-Moo Lim, M.D., Ph.D.3 |
Affiliation |
원자력의학원 핵의학연구실1, 핵의학과2, 한국원자력연구소 하나로이용연구단 동위원소이용연구부3 Laboratory of Nuclear Medicine1, Department of Nuclear Medicine2, Korean Institute of Radiological & Medical Science and Hanaro Application Research3, Korea Atomic Energy Research Institute |
Abstract |
Purpose: Ethylenediamine-tetramethylenephosphonic acid (EDTMP) has widely used chelator for the labeling of
bone seeking radiopharmaceuticals complexed with radiometals. 153Sm can be produced by the HANARO reactor
at the Korea Atomic Energy Research Institute, Taejon, Korea. 153Sm has favourable radiation characteristics
T1/2=46.7 h, βmax=0.81 MeV (20%), 0.71 MeV (49%), 0.64 MeV (30%) and γ=103 keV (30%) emission which is
suitable for imaging purposes during therapy. We investigated the labeling condition of 153Sm-EDTMP and imaging
of 153Sm-EDTMP in normal rats. Materials and methods: EDTMP 20 mg was solved in 0.1 mL 2 M NaOH.
153SmCl3 was added to EDTMP solution and pH of the reaction mixtures was adjusted to 8 and 12, respectively.
Radiochemical purity was determined with paper chromatography. After 30 min. reaction, reaction mixtures were
neutralized to pH 7.4, and the stability was estimated upto 120 hrs. Imaging studies of each reaction were
perfomed in normal rats (37 MBq/0.1 mL). Results: The labeling yield of 153Sm-EDTMP was 99%. The stability of
pH 8 reaction at 60, 96 and 120 hr was 99%, 95%, 89% and that of pH 12 at 36, 60, 96 and 120 hr was 99%,
95%, 88%, 66%, respectively. The 153Sm-EDTMP showed constantly higher bone uptake from 2 to 48 hr after
injection. Conclusion: 153Sm-EDTMP, labeled at pH 8 reaction condition, has been stably maintained. Image of
153Sm-EDTMP at 2, 24, 48 hr after injection, demonstrate that 153Sm-EDTMP is a good bone seeking
radiopharmaceuticals.(Korean J Nucl Med 39(1):44-48, 2005) |
Keyword |
153Sm, EDTMP, radiopharmaceuticals |
Full text Article |
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