심전도 게이트 심근관류 Tl-201 SPECT로 측정된 좌심실 기능 및 좌심실 용적의 정확성 (Accuracy of Ventricular Volume and Ejection Fraction Measured by Gated Tl-201 Perfusion Single Photon Emission Tomography) |
Author |
배문선1,2·문대혁1,3, |
Moonsun Pai, M.D.1,2, Dae Hyuk Moon, M.D.1,3 |
Affiliation |
울산대학교 의과대학 핵의학교실1, 이화여자대학교 의과대학 목동병원 방사선과2 Department of Nuclear Medicine, University of Ulsan College of Medicine, Seoul, Korea1 |
Abstract |
Electrocardiogram-gated single photon emission computed tomography (SPECT) provides valuable information in the
assessment of both myocardial perfusion and ventricular function. Tl-201 is a suboptimal isotope for gating. Tl-201
images are more blurred compared with Tc-99m tracers due to the increased amount of scattered photons and
use of a smooth filter. The average myocardial count densities are approximately one-half those of conventional
technetium tracers. However, Tl-201 is still widely used because of its well-established utility for assessing
myocardial perfusion, viability and risk stratification. Gated SPECT with Tl-201 enables us to assess both post-stress
and rest left ventricular volume and function. Previous studies with gated Tl-201 SPECT measurements of ejection
fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV) have shown high correlation with first-pass
radionuclide angiography, gated blood pool scan, Tc-99m-MIBI gated SPECT, contrast ventriculography,
echocardiography, and 3-dimensional magnetic resonance imaging. However, problems related to these studies
include few agreement data of EDV and ESV, use of a reference method that is likely to have the same systemic
errors (gated Tc-99m-MIBI SPECT), and other technical factors related to the count density of gated SPECT. With
optimization of gated imaging protocols and more validation studies, gated Tl-201 SPECT would be an accurate
method to provide perfusion and function information in patients with coronary artery disease.(Korean J Nucl Med
39(2):94-99, 2005) |
Keyword |
Electrocardiogram-gated Tl-210 myocardial perfusion SPECT, Left ventricular volum, Ejection fraction |
Full text Article |
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