대한핵의학회지 (1967년~2009년)
Nucl Med Mol Imaging 2006;40(1)9~15
악성 및 양성 갑상선 질환의 조직에서 면역조직학적 검사법에 의한 Na+/I- symporter의 발현율 비교
(Comparison of Na+/I- Symporter Expression Rate in Malignant and Benign Thyroid Diseases: Immunohistochemical Study)
Author 강도영1,정영진1,이경은2,박헌수3,유영현4,노미숙2,5,
Do-Young Kang, M.D.1, Young Jin Jeong, M.D.1, Kyung Eun Lee2, Heon-Soo Park, M.D.3, Young Hyun Yoo, M.D.4, and Mee Sook Roh, M.D.2,5
Affiliation 동아대학교 의과대학 핵의학교실1, 암분자치료연구센터2, 이비인후과학교실3, 의과학연구소4, 병리학교실5
1Department of Nuclear Medicine, 2Medical Research Center for Cancer Molecular Therapy, 3Department of Otolaryngology-Head and Neck Surgery, 4Medical Science Research Center, and 5Department of Pathology, Dong-A University College of Medicine, Busan, Kore
Abstract

Purpose: Previous studies have not showed consistent results for the level of expression of sodium/iodide symporter (NIS) in thyroid diseases, especially malignant tumor. We undertook this study to evaluate the distribution of NIS expression in malignant thyroid diseases and compare with that in benign thyroid disease. Materials and Methods: Total patients were 119 cases (Men 15, 48¡¾13 yrs). Total number of samples were 205 pieces. In malignant thyroid disease, there were 153 samples: 90 in papillary carcinoma, 4 in follicular carcinoma, 2 in medullary carcinoma and 57 in metastatic lymph node. In benign thyroid disease, there were 52 samples: 36 in goiter/cyst, 11 in thyroiditis and 5 in follicular adenoma. Using immunohistochemical methods, we probed 205 samples with monoclonal anti-NIS Ab. Grading of staining was scored as 0 (negative or absent), 1 (weakly positive), 2 (moderately positive) or 3 (strongly positive). Expression rate (ER) of NIS positivity in individual disease entity was expressed as percentage of total number divided by number in 2 plus 3 grade. Results: ERs of malignant thyroid diseases were 63% in papillary carcinoma, 81% in metastatic lymph node, 71% in follicular carcinoma and 100% in medullary carcinoma. ERs of benign thyroid disease were 53% in goiter/cyst, 64% in thyroiditis and 40% in follicular adenoma. ER of malignant thyroid diseases was higher than benign thyroid diseases (71% vs 54%). Grading of NIS expression in papillary carcinoma or goiter/cyst was heterogeneously distributed in considerable cases. Normal tissue also showed heterogeneous distribution of NIS expression, which was not correlated with that of primary lesion. Conclusion: In papillary thyroid carcinoma, distribution of NIS expression was heterogeneous and increased, and not different compared with that of benign thyroid disease. (Nucl Med Mol Imaging 2006;40(1):9-15)

Keyword sodium/iodide symporter(NIS), immunohistochemistry, thyroid carcinoma, benign thyroid disease
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