수술로 제거된 비소세포폐암의 예후 예측에 있어 FDG-PET 최대 표준화 섭취계수의 유용성 (Prognostic Usefulness of Maximum Standardized Uptake Value on FDG-PET in Surgically Resected Non-small-cell Lung Cancer) |
Author |
Xuan Canh Nguyen1,이원우1,성숙환2,전상훈2,김유경1,이동수1,정준기1,이명철1,김상은1, |
Xuan Canh Nguyen, M.D.1, Won Woo Lee, M.D.1, Sook Whan Sung, M.D.2, Sanghoon Jheon, M.D.2,Yu Kyeong Kim, M.D.1, Dong Soo Lee, M.D.1, June-Key Chung, M.D.1, Myung Chul Lee, M.D.1, and Sang Eun Kim, M.D.1 |
Affiliation |
서울대학교 의과대학 핵의학교실1, 흉부외과학교실2 .1Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea; 2Department of Thoracic Surgery, Seoul National University College of Medicine, Seoul, Korea |
Abstract |
Purpose: FDG uptake on positron emission tomography (PET) has been considered a prognostic indicator in
non-small cell lung cancer (NSCLC). The aim of this study was to assess the clinical significance of maximum value
of SUV (maxSUV) in recurrence prediction in patients with surgically resected NSCLC. Materials & methods:
NSCLC patients (n=42, F:M=14:28, age 62.3±12.3 y) who underwent curative resection after FDG-PET were
enrolled. Twenty-nine patients had pathologic stage I, and 13 had pathologic stage II. Thirty-one patients were
additionally treated with adjuvant oral chemotherapy. MaxSUVs of primary tumors were analyzed for correlation
with tumor recurrence and compared with pathologic or clinical prognostic indicators. The median follow-up
duration was 16 mo (range, 3-26 mo). Results: Ten (23.8%) of the 42 patients experienced recurrence during a
median follow-up of 7.5 mo (range, 3-13 mo). Univariate analysis revealed that disease-free survival (DFS) was
significantly correlated with maxSUV (<7 vs. ≥7, p=0.006), tumor size (<3 cm vs. ≥3 cm, p=0.024), and tumor
cell differentiation (well/moderate vs. poor, p=0.044). However, multivariate Cox proportional analysis identified
maxSUV as the single determinant for DFS (p=0.014). Patients with a maxSUV of ≥7 (n=10) had a significantly
lower 1-year DFS rate (50.0%) than those with a maxSUV of <7 (n=32, 87.5%). Conclusion: MaxSUV is a
significant independent predictor for recurrence in surgically resected NSCLC. FDG uptake can be added to other
well-known factors in prognosis prediction of NSCLC. (Nucl Med Mol Imaging 2006;40(4):205-210)
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Keyword |
FDG uptake, non-small-cell lung cancer, positron emission tomography, F-18 fluorodeoxyglucose, prognosis |
Full text Article |
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