종양 표적 유전자 치료 (Tumor targeted gene therapy) |
Author |
강주현, |
Joo Hyun Kang, Ph.D. |
Affiliation |
원자력의학원 핵의학연구실 Laboratory of Nuclear Medicine, Korea Institute of Radiological and Medical Science, Seoul, Korea |
Abstract |
Knowledge of molecular mechanisms governing malignant transformation brings new opportunities for therapeutic
intervention against cancer using novel approaches. One of them is gene therapy based on the transfer of genetic
material to an organism with the aim of correcting a disease. The application of gene therapy to the cancer
treatment has led to the development of new experimental approaches such as suicidal gene therapy, inhibition of
oncogenes and restoration of tumor-suppressor genes. Suicidal gene therapy is based on the expression in tumor
cells of a gene encoding an enzyme that converts a prodrug into a toxic product. Representative suicidal genes
are Herpes simplex virus type 1 thymidine kinase (HSV1-tk) and cytosine deaminase (CD). Especially, physicians and
scientists of nuclear medicine field take an interest in suicidal gene therapy because they can monitor the
location and magnitude, and duration of expression of HSV1-tk and CD by PET scanner.(Nucl Med Mol Imaging
2006;40(5):237-242)
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Keyword |
gene therapy, PET imaging, prodrug therapy, suicidal gene therapy, tumor targeting |
Full text Article |
4005237.pdf
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