간의 18F-Fluorodeoxyglucose 섭취 양상과 지방간의 관계 (Correlation of Hepatic 18F-Fluorodeoxyglucose Uptake with Fatty Liver) |
Author |
안영실,윤준기,홍선표,조철우,윤석남, |
Young-Sil An, M.D., Joon-Kee Yoon, M.D., Seon Pyo Hong, M.D., Chul-Woo Joh, Ph.D. and Seok-Nam Yoon, M.D. |
Affiliation |
아주대학교 의과대학 핵의학교실 Department of Nuclear Medicine and Molecular Imaging, Ajou University School of medicine, Suwon, Kyungki-do, Korea |
Abstract |
Purpose: Liver demonstrates heterogeneous FDG uptake and sometimes it shows abnormally increased uptake
even though there is no malignant tissue. However, there was no previous study to correlate these various
pattern of hepatic FDG uptake with benign liver disease. Therefore, we evaluated the significance of hepatic FDG
uptake associated with various clinical factors including fatty liver, liver function tests and lipid profiles. Materials
and Methods: We reviewed a total of 188 patients (male/female: 120/68, mean age: 50±9) who underwent
PET/CT for screening of malignancy. Patients with DM, impaired glucose tolerance, previous severe hepatic disease
or long-term medication history were excluded. The FDG uptake in liver was analyzed semi-quantitatively using
ROI on transaxial images (segment 8) and we compared mean standardized uptake value (SUV) between fatty liver
and non-fatty liver group. We also evaluated the correlation between hepatic FDG uptake and various clinical
factors including serum liver function test (ALT, AST), γ-GT, total cholesterol and triglyceride concentration. The
effect of alcoholic history and body mass index on hepatic FDG uptake was analyzed within the fatty liver
patients. Results: The hepatic FDG uptake of fatty liver group was significantly higher than that of non-fatty liver
group. Serum total cholesterol and triglyceride concentration showed significant correlation with hepatic FDG
uptake. However, there was no significant correlation between other factors (ALT, AST, and γ-GT) and FDG
uptake. Also there was no difference of mean SUV between normal and abnormal groups on the basis of
alcoholic history and body mass index within fatty liver patients. Fatty liver and high serum triglyceride
concentration were the independent factors affecting hepatic FDG uptake according to multivariate analysis.
Conclusion: In conclusion, hepatic FDG uptake was strongly correlated with fatty liver and serum triglyceride
concentration. (Nucl Med Mol Imaging 2006;40(5):243-248) |
Keyword |
FDG, PET, fatty liver, triglyceride, hepatitis, liver function test |
Full text Article |
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