대한핵의학회지 (1967년~2009년)
Nucl Med Mol Imaging 2006;40(6)322~326
갑상선암의 방사성요오드치료를 위한 저요오드식이 방법 차이에 따른 소변 중 요오드/크레아티닌 비의 비교
(Comparison of Urine Iodine/Creatinine ratio between Patients following Stringent and Less Stringent Low Iodine Diet for Radioiodine Remnant Ablation of Thyroid Cancer)
Author 노지호1, 김병일2,3, 하지수, 장세중, 신혜영, 최준혁, 김도민1, 김종순2,3,
Jee Ho Roh, M.D.1, Byung Il Kim, M.D.2,3, Ji Su Ha, M.D., Sei Joong Chang, M.D., Hye Young Shin, M.D., Joon Hyuk Choi, M.D., Do Min Kim, M.D.1, and Chong Soon Kim, M.D.2,3
Affiliation 한일병원 내과1, 핵의학과2, 방사선보건연구원3
Departments of Internal Medicine1 and Nuclear Medicine2, Han-il Hospital, Radiation Health Research Institute3, Seoul, Korea
Abstract

A low iodine diet (LID) for 1~2 weeks is recommended for patients who undergoing radioiodine remnant ablation. However, the LID educations for patients are different among centers because there is no concrete recommendation for protocol of LID. In this investigation, we compared two representative types of LID protocols performed in several centers in Korea using urine iodine to creatinine ratio (urine I/Cr). Methods: From 2006, April to June, patients referred to our center for radioiodine remnant ablation of thyroid cancer from several local hospitals which had different LID protocols were included. We divided into two groups, stringent LID for 1week and less stringent LID for 2 weeks, then measured their urine I/Cr ratio with spot urine when patients were admitted to the hospital. Results: Total 27 patients were included in this investigation (M:F=1:26; 13 in one-week stringent LID; 14 in two-week less stringent LID). Average of urine I/Cr ratio was 127.87±78.52 ㎍/g in stringent LID for 1 week, and 289.75±188.24 ㎍/g in less stringent LID for 2 weeks. It was significantly lower in stringent LID for 1 week group (p=0.008). The number of patients whose urine I/Cr ratios were below 100 μg/g was 6 of 13 in stringent LID for 1 week group, and 3 of 14 in less stringent LID for 2 weeks group. Conclusion: Stringent LID for 1 week resulted in better urinary I/Cr ratio in our investigation compared with the other protocol. However it still resulted in plenty of inadequate range of I/Cr ratio, so more stringent protocol such as stringent LID for 2 weeks is expected more desirable. (Nucl Med Mol Imaging 2006;40(6):322-326)

Keyword urine I/Cr ratio, low iodine diet, radioiodine remnant ablation, I-131 therapy, thyroid cancer
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