대한핵의학회지 (1967년~2009년)
Nucl Med Mol Imaging 2007;41(6)530~537
초기 단계의 피질하 혈관성 치매와 알쯔하이머병에서 Tc-99m HMPAO SPECT 영상 소견 차이
(Differences of Tc-99m HMPAO SPECT Imaging in the Early Stage of Subcortical Vascular Dementia Compared with Alzheimer's Disease)
Author 박경원1·강도영2·박민정1·천상명1·차재관1·김상호1·김재우1,
Kyung Won Park, M.D.1, Do-Young Kang, M.D.2, Min Jeong Park, M.D.1, Sang Myung Cheon, M.D.1, Jae Kwan Cha, M.D.1, Sang-Ho Kim, M.D.1, and Jae Woo Kim, M.D.1
Affiliation 동아대학교 의과대학 신경과학교실1, 핵의학교실2
Departments of 1Neurology and 2Nuclear Medicine, College of Medicine, Dong-A University, Busan, Korea
Abstract

Purpose: The aim of this study is to assess the specific patterns of regional cerebral blood flow (rCBF) in patients with the early stage of subcortical vascular dementia (SVaD) and Alzheimer's disease (AD) using Tc-99m HMPAO SPECT, and to compare the differences between the two conditions. Materials and Methods: Sixteen SVaD, 46 AD and 12 control subjects participated in this study. We included the patients with SVaD and AD according to NINCDS-ADRDA and NINDS-AIREN criteria. They were all matched for age, education and clinical dementia rating scores. Three groups were evaluated by Tc-99m HMPAO SPECT using statistical parametric mapping (SPM) for measuring rCBF. The SPECT data of patients with SVaD and AD were compared with those of normal control subjects and then compared with each other. Results: SPM analysis of the SPECT image showed significant perfusion deficits on the right temporal region and thalamus, left insula and superior temporal gyrus, both cingulate gyri and frontal subgyri in patients with SVaD and on the left supramarginal gyrus, superior temporal gyrus, postcentral gyrus and inferior parietal lobule, right fugiform gyrus and both cingulate gyri in AD compared with control subjects (uncorrected p<0.01). SVaD patients revealed significant hypoperfusion in the right parahippocampal gyrus with cingulated gyrus, left insula and both frontal subgyral regions compared with AD (uncorrected p<0.01). Conclusion: Our study shows characteristic and different pattern of perfusion deficits in patients with SVaD and AD, and these results may be helpful to discriminate the two conditions in the early stage of illness. (Nucl Med Mol Imaging 2007;41(6):530-537)

Keyword subcortical vascular dementia, Alzheimer's disease, statistical parametric mapping analysis, cerebral perfusion SPECT
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