기체 크로마토그래피를 이용한 [18F]FDG 주사액 중의 잔류 용매의 정도관리
(Quality Control of Residual Solvents in [18F]FDG Preparations by Gas Chromatography) |
| Author |
이학정1,2·정재민1,2,3·이윤상1,2·김형우1,3·장영수1·이동수1·정준기1,3·이명철1,2, |
| Hak Jeong Lee, B.S.1,2, Jae Min Jeong, Ph.D.1,2,3, Yun-Sang Lee, Ph.D.1,2, Hyung Woo Kim, M.S.1,3, Young Soo Chang, Ph.D.1, Dong Soo Lee, M.D.1, June-Key Chung, M.D.1,3, and Myung Chul Lee, M.D.1,2 |
| Affiliation |
서울대학교 의과대학 핵의학교실 및 의학연구원 방사선의학연구소1, 서울대학교병원 임상의학연구소2, 서울대학교 의과대학 암 연구소3
1Department of Nuclear Medicine, College of Medicine and Institute of Radiation Medicine, Medical Research Center, Seoul National University, 2Clinical Research Institute, Seoul National University Hospital, Seoul, Korea; 3Cancer Research Institute, Seoul |
| Abstract |
Purpose: Analysis of volatile organic solvents in 2-deoxy-2-[18F] fluoro-D-glucose ([18F]FDG) preparations was performed by gas chromatography (GC), in accordance with USP. Materials and Methods: Analyses were carried out on a Hewlett-Packard 6890 gas chromatography equipped with an FID. Results: We determined the amounts of ethanol and acetonitrile on every batch of our routine [18F]FDG preparations, ranging between 5000 ppm and 100 ppm. In our routine preparation of [18F]FDG, the amount of acetonitrile and ethanol in the final product were
well below the maximum allowable limit described in the USP. Conclusion: Our [18F]FDG preparations were in accordance with the suggested USP maximum allowable levels of the quality control analysis of volatile organic compounds. (Nucl Med Mol Imaging 2007;41(6):566-569) |
| Keyword |
residual solvents, [18F]FDG, gas chromatography, quality control |
| Full text Article |
4106569.pdf 
|
|
|
