이오도늄 솔트 전구체를 이용한 새로운 방향족 화합물 플루오린-18 표지 기술 (A Novel Aromatic Fluorine-18 Labeling Method Using Iodonium Salts Precursor) |
Author |
문병석, 이병철, 김상은, |
Byung Seok Moon, Byung Chul Lee, and Sang Eun Kim |
Affiliation |
서울대학교 의학연구원 방사선 의학연구소, 분당서울대학교병원 핵의학과 Institute of Radiation Medicine, Seoul National University Medical Research Center & Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, Korea |
Abstract |
As many new drug substances contained various aromatic rings and fluorine attached to an electron rich aromatic ring or on the meta-position, a strategy towards improvement in aromatic fluorination of these compounds is highly desirable. The introduction of fluorine-18 onto aromatic rings showed in the limited condition containing electron withdrawing group (EWG) on the para- or ortho-position to get reasonable radiochemical yield so far. No-carrier added (NCA) [18F]fluoroarene syntheses by iodonium salts recently reported that has the potential to greatly increase the yield in systems or positions that normally not reactive enough to give sufficient yields in simple model reaction. This review describes the methodological approach towards effective aromatic fluorination by diaryliodonium salts and future prospects in an application of novel PET radiotracer. (Nucl Med Mol Imaging 2009;43(1):1-9) |
Keyword |
Aromatic fluorination, fluorine-18, diaryliodonium salts, PET |
Full text Article |
4301001009.pdf
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