대한핵의학회지 (1967년~2009년)
Nucl Med Mol Imaging 2009;43(1)72~78
쥐에서 이중에너지 방사선 흡수법을 이용한 골밀도의 측정: 다양한 골부위에서 재위치 여부에 따른 생체내 측정의 정밀도
(Bone Mineral Density Measurement of Rats Using Dual-energy X-ray Absorptiometry: Precision of In Vivo Measurements for Various Skeletal Sites with or without Repositioning)
Author 오동현, 정재호, 우상근, 천기정 ,김병일, 최창운, 임상무,
Dong Hyun Oh, Jae Ho Jung, Sang Keun Woo, Gi Jeong Cheon, Byung Il Kim, Chang Woon Choi, and Sang Moo Lim,
Affiliation 한국원자력의학원 핵의학과1, 핵의학기초연구팀2
1Department of Nuclear Medicine and 2Lab. of Nuclear Medicine Basic Research,
Abstract

Purpose: Bone mineral density (BMD) measurements need to be precise enough to be capable of detecting small changes in bone mass of rats. Using a regular dual-energy X-ray absorptiometry (DXA), we measured many BMD of various skeletal sites in rats to examine precision of DXA in relation to the repositioning on the bones of rats. Materials and Methods: Using DXA and small animal software, scans were performed 4 times in all 12 male rats without repositioning (Group 1a). Another four scans for 6 of 12 rats were done with repositioning between scans (Group 2). Customized regions of interest (ROIs), encapsulate the right hind limb, L1-4, skull and pelvic bones were drawn at each measurement. The precision of the measurements was evaluated by measuring the coefficient of variation (CV) of four measurements of BMD at each skeletal site of all rats with or without repositioning. Significance of differences between group 1b (six rats out of group 1a, which were come under group 2) and group2 were evaluated with Wilcoxon Signed Rank Sum Test. Results: CVs obtained at different skeletal sites of all measurements in Group 1b and 2. It was 3.51¡¾1.20, 2.62¡¾1.20 for the hindlimb (p=0.173), 3.83¡¾2.02, 4.59¡¾2.02 for L1-4 (p=0.600), 3.73¡¾1.87, 1.53¡¾0.89 for skull (p=0.046), and 2.92¡¾0.60, 1.45¡¾0.60 for pelvic bones (p=0.075). Conclusion: Our study demonstrates that the DXA technique has the precision necessary when used to assess BMD for various skeletal sites in rats regardless of repositioning. (Nucl Med Mol Imaging 2009;43(1):72-78)

Keyword DXA, BMD, precision, rat, repositioning
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