대한핵의학회지 (1967년~2009년)
Nucl Med Mol Imaging 2009;43(2)100~106
파킨슨병과 본태성 진전의 감별진단에서 I-123 IPT(I-123-N-(3-iodopropen-2-yl)-2β-carbomethoxy-3β-(4-cholorophenyl) tropane) 뇌 단일광전자방출 전산화단층촬영의 역할
(Differentiation of Parkinson's Disease and Essential Tremor on I-123 IPT(I-123-N-(3-iodopropen-2-yl)-2β-carbomethoxy-3β-(4-cholorophenyl) tropane) Brain SPECT)
Author 배문선1, 최태현2, 안성민3, 최재용4, 류원기4, 이재훈4, 유영훈4,
Moonsun Pai, M.D.1, Tae Hyun Choi, Ph.D.2, Sung Min Ahn, M.S3, Jai Yong Choi, M.S.4, Won Gee Ryu, M.D.4, Jae-Hoon Lee, M.D.4 and Young Hoon Ryu, M.D.4
Affiliation 관동대학교 의과대학 핵의학과1, 한국원자력의학원 핵의학과2, 가천길대학 방사선과3, 연세대학교 의과대학 핵의학과4
1Department of Nuclear Medicine, Kwandong University College of Medicine, Koyang, Korea; 2Department of Nuclear medicine, Korea Institute of Radiological and Medical Science, Seoul, Korea; 3Department of Diagnostic Radiology, Gachon University of Medicine
Abstract

Purpose: The study was to assess I-123-N-(3-iodopropen-2-yl)-2[beta]-carbomethoxy-3[beta]-(4-cholorophenyl) tropane (IPT) SPECT in differential diagnosis among early stage of Parkinson’s disease(PD) and essential tremor(ET) and normal control(NL) groups quantitatively. Materials and Methods: I-123 IPT brain SPECT of 50 NL, 20 early PD, 30 advanced PD, and 20 ET were performed at 20 minutes and 2 hours. Specific/nonspecific binding of striatum was calculated by using right and left striatal specific to occipital non-specific uptake ratio (striatum-OCC/OCC). Results: Mean value of specific/nonspecific binding ratio was significantly different between advanced PD group and NL group. However, significant overlap of striatal specific/nonspecific binding ratio was observed between PD group and ET group. Bilateral striatal specific/nonspecific binding ratios were decreased in advanced PD. Lateralized differences in the striatal uptake of I-123 IPT correlated with asymmetry in clinical findings in PD group. Conclusion: I-123 IPT SPECT may be a useful method for the diagnosis of PD and objective evaluation of progress of clinical stages. Care should be made in the differential diagnosis of early stage of PD and other motor disturbances mimicking PD such as ET in view of significant overlap in striatal I-123 specific/nonspecific binding ratio. (Nucl Med Mol Imaging 2009;43(2):100-106)

Keyword Dopamine transporter, I-123 IPT SPECT, essential tremor, Parkinson' disease
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