대한핵의학회지 (1967년~2009년)
Nucl Med Mol Imaging 2009;43(4)280~286
기저/아세타졸아미드 국소뇌혈류 SPECT의 확률 뇌지도 분석을 이용한 일측 중대뇌동맥 협착환자에서 시행한 스텐트 삽입술의 효용성 평가
(Efficacy Assessment of Endovascular Stenting in Patients with Unilateral Middle Cerebral Artery Stenosis Using Statistical Probabilistic Anatomical Mapping Analysis of Basal/Acetazolamide Brain Perfusion SPECT)
Author 김해원1, 원경숙1, 전석길1,3, 이창영2,3,
Hae Won Kim, M.D.1, Kyoung Sook Won, M.D.1, Seok Kil Zeon, M.D.1,3, and Chang-Young Lee, M.D.2,3
Affiliation 계명대학교 동산의료원 핵의학과1, 신경외과2, 뇌연구소3
Department of 1Nuclear Medicine and 2Neurosurgery, 3Brain Research Institute, Keimyung University, School of Medicine, Daegu, Korea
Abstract

Purpose: The aim of this study was to evaluate the hemodynamic changes after endovascular stenting in patients with unilateral middle cerebral artery (MCA) stenosis using statistical probabilistic anatomical mapping (SPAM) analysis of basal/acetazolamide (ACZ) Tc-99m ECD brain perfusion SPECT. Materials and Methods: Eight patients (3 men and 5 women, 64.8¡¾10.5 years) who underwent endovascular stenting for unilateral MCA stenosis were enrolled. Basal/ACZ Tc-99m ECD brain perfusion SPECT studies were performed by one-day protocol before and after stenting. Using SPAM analysis, we compared basal cerebral perfusion (BCP) counts and cerebrovascular reserve (CVR) index of the MCA territory before stenting with those after stenting. Results: After stenting, no patient had any complication nor additional stroke. In SPAM analysis, 7 out of the 8 patients had improved BCP counts of the MCA territory and 7 out of the 8 patients had improved CVR index of the MCA territory after stenting. Before stenting, the mean BCP counts and CVR index in the affected MCA territory were 47.1¡¾2.2 ml/min/100 g and -2.1¡¾2.9%, respectively. After stenting, the mean BCP counts and CVR index in the affected MCA territory were improved significantly (48.3¡¾2.9 ml/min/100 g, p=0.025 and 0.1¡¾1.3%, p=0.036). Conclusion: This study revealed that SPAM analysis of basal/ACZ brain perfusion SPECT would be helpful to evaluate hemodynamic efficacy of endovascular stenting in unilateral MCA stenosis. (Nucl Med Mol Imaging 2009;43(4):280-286)

Keyword Tc-99m ECD, statistical probabilistic anatomical mapping, stents, middle cerebral artery, stenosis
Full text Article 04_김해원.pdf 04_김해원.pdf
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