유방암 절제술 후 방사선치료를 시행한 환자의 골스캔에서 보이는 방사선 유발 늑골골절 (Radiation Induced Rib Fractures on Bone Scan after Breast Cancer Surgery and Radiation Therapy) |
Author |
김해원1, 원경숙1, 전석길1, 김진희2, |
Hae Won Kim, M.D.1, Kyoung Sook Won, M.D.1, Seok Kil Zeon, M.D.1, and Jin Hee Kim, M.D.2 |
Affiliation |
계명대학교 동산의료원 핵의학과1, 방사선종양학과2 Departments of 1Nuclear Medicine and 2Radiation Oncology, Keimyung University, School of Medicine, Daegu, Korea |
Abstract |
Purpose: This study is to evaluate rib fractures on bone scan in breast cancer patients treated with breast cancer surgery and radiation therapy and to evaluate its relation with radiation therapy and operation modality. Materials and Methods: Two hundred seventy cases that underwent serial bone scan after breast cancer surgery and radiation therapy were enrolled. Bone scan and chest CT findings of rib fracture were analyzed. Results: The rib uptake was seen in 74 of 270 cases (27.4%) on bone scan and 50 cases (18.5%) were confirmed to have rib fracture by chest CT. The rate of modified radical mastectomy in patients with rib fracture was significantly higher than that in patients without rib fracture (66.0% vs. 27.0%, p=0.000). The rate of additional radiation therapy to axillar or supraclavicular regions in patients with rib fracture was significantly higher than that in patients without rib fracture (62.0% vs. 28.6%, p=0.000). Rib fracture was seen most frequently at 1-2 years after radiation therapy (51.9%) and single rib fracture was seen most frequently (55.2%). Of total 106 rib fractures, focal rib uptake was seen in 94 ribs (88.7%) and diffuse rib uptake was seen in 12 ribs (11.3%). On one year follow-up bone scan, complete resolution of rib uptake was seen in 15 ribs (14.2%). On chest CT, the rate of fracture line in ribs with intense uptake was significantly higher than that in ribs with mild or moderate uptake (p=0.000). The rate of presence of fracture line in ribs with focal uptake was significantly higher than that in ribs with diffuse uptake (p=0.001). Conclusion: Rib fracture in breast cancer patients after radiation therapy was related to radiation portal and operation modality. It should be interpreted carefully as a differential diagnosis of bone metastasis. (Nucl Med Mol Imaging 2009;43(4):287-293)
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Keyword |
Breast cancer, bone scan, radiation therapy, rib fracture |
Full text Article |
05_김해원.pdf
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