처음 진단된 두경부 선양낭성암종에서 18F-FDG PET/CT: 임상상 및 병리소견과의 상관성 (18F-FDG PET/CT in Patients with Initially Diagnosed Adenoid Cystic Carcinoma of the Head and Neck: Clinicoplathologic Correlation) |
Author |
이지영1, 최준영1, 고영혜2, 백정환3, 손영익3, 조숙경1, 천미주1, 이경한1, 김병태1, |
Ji Young Lee, M.D.1, Joon Young Choi, M.D.1, Young Hyeh Ko, M.D.2, Chung-Hwan Baek, M.D.3, |
Affiliation |
성균관대학교 의과대학 삼성서울병원 핵의학과1, 병리과2, 이비인후-두경부외과3 Departments of 1Nuclear Medicine, 2Pathology, and 3Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea |
Abstract |
Purpose: We evaluated 18F-FDG PET/CT findings in initially diagnosed adenoid cystic carcinoma (ACC) of the head and neck in association with pathological subtype, staging, uptake comparison with squamous cell carcinoma (SqCC) and prognosis. Materials and Methods: The subjects were 16 patients with initially diagnosed ACC of head and neck who underwent pretreatment 18F-FDG PET/CT. Histological subtype (solid pattern vs. tubular/cribriform pattern), SUVmax of size-matched SqCC of the head and neck as control group, disease-free survival (DFS) were compared with the SUVmax of ACC of the head and neck. Results: Of total 16 patients, 6 had solid pattern and the remaining 10 had tubular/cribriform pattern. The SUVmax were significantly higher in solid pattern group than in tubular/cribriform pattern group (6.7±3.2 vs. 4.2±0.9, p=0.03). PET/CT found unexpected distant metastasis in 18.7% of patients (3/16) and changed the therapeutic plan in those patients. The SUVmax of ACC was significantly lower than that of size-matched SqCC (5.1±2.4 vs. 13.6±6.0, p<0.001). DFS was not significantly different according to the histological subtype. In contrast, patients with high 18F-FDG uptake (SUVmax ≥6.0) had significantly shorter DFS than those with low 18F-FDG uptake (SUVmax <6.0). Conclusion: 18F-FDG uptake of ACC of the head and neck is significantly associated with histological subtype and DFS. 18F-FDG PET/CT may be useful for detecting unexpected metastasis. Since 18F-FDG uptake of tubular/cribriform ACC compared with SqCC is relatively low, it is necessary to interpret PET images carefully in patients without alleged ACC. |
Keyword |
PET/CT, 18F-FDG, adenoid cystic carcinoma, head and neck, prognosis |
Full text Article |
04_이지영.pdf
|
|
|