대한핵의학회지 (1967년~2009년)
Nucl Med Mol Imaging 2009;43(6)535~542
방사선치료 반응도 예측을 위한 예비 연구: [18F]FDG PET와의 비교
(Pilot Study for the Prediction of Response to Radiotherapy Using [18F]Fluorothymidine PET in Nasopharyngeal Cancer: Comparison with [18F]FDG PET)
Author 백소라1, 채선영1, 김혜옥1, 이상욱2, 오승준1, 임기천1, 문대혁1, 김재승1, 류진숙1,
Sora Baek, M.D.1, Sun-Young Chae, M.D.1, Hye-Ok Kim, M.D.1, Sang-Wook Lee, M.D.2, Seung Jun Oh, Ph.D.1, Ki Chun Im, Ph.D.1, Dae Hyuk Moon, M.D.1, Jae Seung Kim, M.D.1, and Jin-Sook Ryu, M.D.1
Affiliation 울산대학교 의과대학 서울아산병원 핵의학과1, 방사선 종양학과2
Departments of 1Nuclear Medicine and 2Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Abstract

Purpose: This study was performed to know whether [18F]Fluorothymidine (FLT) positron emission tomography (PET) can be used to monitor early response to radiotherapy in comparison with [18F]Fluorodeoxyglucose (FDG) PET, and to establish the optimal imaging time for prediction of therapy response. Materials and Methods: Two patients with nasopharyngeal cancer underwent serial FLT PET and FDG PET before and during radiotherapy. Three on- treatment FLT and FDG PET scans were performed on 1 week, 2 weeks and 3 weeks (at each time of 10 Gy, 20 Gy and 30 Gy delivered). The peak standardized uptake values (SUVpeak) of primary tumors were measured on FLT and FDG PET. Then, percent changes of SUVpeak after therapy were calculated. Results: In two patients, baseline values of SUVpeak on FDT PET were higher than those on FLT PET (FLT vs FDG; 3.7 vs 5.0, and 5.7 vs 15.0). In patient 1, FLT SUVpeak showed 78%, 78% and 84% of decrease on 1 week, 2 and 3 weeks after treatment, whereas FDG SUVpeak showed 18%, 52% and 66% of decrease, respectively. In patient 2, FLT SUVpeak showed 75%, 75% and 68% of decrease, whereas FDG SUVpeak showed 51%, 49% and 58% of decrease, respectively. Both patients reached to complete remission after radiotherapy. Conclusion: After radiotherapy, the decrease of FLT tumor uptake preceded the decrease of FDG tumor uptake in patients with nasopharyngeal cancer, and 1 week after therapy may be appropriate time for the assessment of early response. FLT PET might be more useful than FDG PET for monitoring early response to radiotherapy.

Keyword [18F]Fluorothymidine , [18F]Fluorodeoxyglucose, PET, nasopharyngeal cancer, radiation therapy
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