The purpose of this study is to evaluate the clinical application of the no carrier added[Cr] Cr(UI) EDTA complexes, produced at Korea Cancer Center Hospital. The [Cr]Cr(lll) EDTA complexes, useful for measurement of GFR were prepared at room temperature in the presence of bicarbonate catalysts. The radiochemical purity of[Cr]Cr (Iil) EDTA was over 99% by paper electrophoresis. The time activity curves were obtained by counting the blood samples from 5 volunteers and counting the head and neck regions with whole body counter after inject#ion of the Cr EBTA, respectively, After the nonlinear regression, the area under curve was obtained. The plasma clearance of the Cr-EDTA was calculated with injected dose/AUC. The clearance rate calculated with the head and neck countmg data was in good agreement with t,he result from the plasma sample radioactivity at, 1-3 hrs after injection. From this result, the counting of head and neck region and the nonlinear regression by 2-compartment model could be applied for the measurement of the clearance rate. Using MIRD system, the absorbed radiation dose was calculated by residence time x S. The absorbed whole body radiation dose was negligibly small.