대한핵의학회지 (1967년~2009년)
대한핵의학회지 1967;1(1)1~19
가토에 있어서 방사선조사와 갑상선이 조혈계에 미치는 영향에 관한 연구 ( A Study on the Effects of the X-Ray Irradiation and Thyroid Gland on the Erythropoietic System in Rabbit )
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Author 김공근(Kong Keun Kim),
Affiliation
Abstract

The effects of X-ray irradiation and the thyroid gland on the erythropoietic system were studied in the white male rabbits. The total body irradiation was done in doses of 250r and 500r to each of 5 rabbits for 10 days. The factors were 220KV, 10mA, FLI/4 Cu+1 mmAl (HVL:2.0mmCu) 50cm F.S.D. The thyroid dysfunction was experimentally induced by giving 2mg of thyroid tablets per kg body weight for 15 days in 5 rabbits for hyperthyroidism and by giving 1.5mC of 131I per kg body weight in another 5 rabbits for hypothyroidism. Fourteen healthy rabbits were used as control. The hematologic changes and ferrokinetic data obtained from 59Fe and apparent half survival of the red blood cells obtained from 51Cr were compared. Following were the results:A. X-ray irradiated group;1) There were no significant changes in hematologic findings except for leucopenia. A slight decrease of red blood cells was observed in 500r irradiated animals. 2) The decrease in the iron turnover rates of the plasma and red blood cells as well as in the red cell renewal rate were found in both groups. A significant decrease of the red cell iron utilization rate was observed in the 500r irradiated animals. 3) The apparent half survival times of the red blood cells were slightly, in the 250r (12.1¡¾0.80 days), and markedly shortened in the 500r irradiated animals (9.8¡¾1.38 days), the normal being 14.0¡¾1.6 days. 4) It appears, therefore, that the anemia caused by X-ray irradiation is due to the inhibition of hemopoietic function and the excess destruction of the red blood cells. B. 1) The slight increase of the red blood cell count and circulating blood volume with the normal serum iron level were observed in the hyperthyoid group, while the decrease of the red and white blood cell counts, hemoglobin and hematocrit values with a marked decrease of the serum iron level in the hypothyroid group. 2) A marked decrease of the plasma iron disappearance rate with increase of plasma iron turnover, red cell iron utilization and red cell iron turnover were observed in the hyperthyroid group, while the marked delay and decrease in the hypothyroid group. 3) The apparent half survival times of the red blood cells were almost the same with the control in the hyperthyroid group, (14.0¡¾1.58 days) while a marked shortening in the hypothyroid group (10.6¡¾0.30 days). 4) It was reconfirmed that the thyroid hormones bear a close relationship with the erythropoietic system, namely, the latter is stimulated by the former. The lack of the thyroid hormones thus induces the bone marrow depression leading to anemia the major cause of which, therfore, is not hemolysis.

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