Abstract |
Fourteen patients with typhoid fever studied by
scanning and clearance-rate measurements of subcritical
dose colloidal radiogold(198Au). Mild to moderate
enlargement of the liver and spleen was noted in 78.6
and 64.3 percent of patients, respectively; and splenic
and spinal bone-marrow uptake was seen in 78.6 and 57.1
percent of cases, respectively. Typically, these scan
changes occurred concomitantly (57.1%) and are
considered to represent increased phagocytic activity
of the RE cells which is characteristic of typhoid
fever. The half clearance-time was significantly
shortened during the first 10-day period of the illness
indicating an increase in the hepatic blood in the
early phase of typhoid infection. Hepatomegaly,
splenomegaly and extrahepatic uptakes along with an
accelerated (or less a normal) clearance time are
characteristic of typhoid fever.
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