Abstract |
Carcinoembryonic antigen(CEA) levels were measured in
the serum of 35 normal control subjects and 179 cases
of various benign and malignant gastrointestinal
diseases. Malignant gastrointestinal tumors include 69
cases of stomach cancer, 24 cases of hepatoma and 33
cases of colorectal cancer. Benign gastrointestinal
diseases include 29 cases of peptic ulcer and 24 cases
of liver cirrhosis. The results were as followings: 1)
Mean serum CEA level in normal control subjects was
6.9¡¾3.3 ng/ml and there was no difference in mean
serum CEA level between age and sex difference. 2) In
malignant gastrointestinal tumors, mean serum CEA level
in colorectal cancer, hepatma and stomach cancer, were
54.3¡¾88.9 ng/ml, 62.1¡¾99.7 ng/ml respectively.
Serum CEA level showed positive rate of 67% in
colorectal cancer, 63% in hepatoma and 625 in stomach
cancer. There was no difference in mean levels and
positivity of serum CEA between these 3 malignant tumor
groups. 3) Positivity of serum CEA was 61% in malignant
gastrointestinal tumor group in spite of 37% in benign
gastrointestinal disease group. In both mean level and
positivity of serum CEA, stomach cancer was much higher
than peptic ulcer. But there was no difference in mean
level and positivity of serum CEA level between
hepatoma and liver cirrhosis. 4) In hepatoma serum CEA
level showed positive rate of 62.5% and alpha-feto
protein showed a rate of 58.3%. 5) Mean serum CEA
levels in patients with cancer in rectal, cecal,
sigmoid colon, ascending colon and descending colon
were 73.7¡¾106.7 ng/ml, 69¡¾84.8 ng/ml, 15.7¡¾9.1
ng/ml, 7.5¡¾10.6 ng/ml and 4.0 ng/ml respectively.
Positive rate of serum CEA showed 86% in sigmoid colon
cancer, 68% in rectal cancer and 66% in cecal cancer.
6) In considering of histological background, there was
no col1elation between the degree of differentiation of
tumor cell and the serum CEA level in colorectal
cancer. According to Duke's classification, the mean
serum levels of CEA were 8.8¡¾11.4 ng/ml in group A,
15.3¡¾16.0 ng/ml in group B and 68. |