To evaluate the effect of dopaminergic activity on aldosterone secretion, the plasma renin activity, serum cortisol and aldosterone were measured by radioimmunoassay in 6 normal controls and 12 patients who had hyponatrernia and generalized edema or ascites with possible condition with secondary aldosteronism before and after(l5,30, and 60 min) 15mg of metoclopramide by iv bolus injection and same method with 500mg of L-dopa by per oral in 6 normal controls and 12 patients with edema ascites. The result were as follows; l) The basal level of PRA was higher in patients rather than norrnal controls but PRA was not influenced by MC or L-dopa adrninistration on both normal controls and patients group. 2) The serum cortisol level was significantly elevated at 30 min after MC injection compared with basal level in normal controls but no significant change was not patients group. After L-dopa administration the serum cortisol level was noted in changed in both normal controls and patients group, 3) The serum aldosterone level was significantly elevated in 15,30 and 60 min after MC injaction in normal controls, and there also same tendency of aldosterone secretion was noticed in patients group. On the other hands, there was no changes in aldosterone level in both normal controls and patients group with L-dopa administration. Above result means that MC stimulate aldosterone secretion by dopaminergic antagonist and aldoaterone secretion in normal subject is controlled by maximaI tonic dopaminergic inbibition. In edematous patients, however, both of the dopaminergic inhibitory and stimulating effect of PRA, ACTH etc o#n the aldosterone secretion seems to be variable.