The fact there are increase of intrapulmonary arterioveneous shunt amount in the liver cirrhosis patient has been known since 1950. And the method of shunt amount calculation by radionuclide method using " Tc-MAA was introduced in the middie of 1970. We measured intrapulmonary shunt amount by means of perfusion lung scan using Tc-MAA in the various type of liver diseases especiatly in chronic liver diseases and acute liver disease. The results were as followed. 1) The amount of arteriovenous intrapulmonary shunt in the total case of liver disease was 9.3+ 3.9%, and that of in the control group was 4.6+2.1%. 2) The arnount of arteriovenous intrapulmonary shunt in the chronic liver disease was 10.8+4.4%, and that of in the acute liver disease was 7.2+2.8%. We observed significant differences between normal control group and liver disease group, and between chronic liver disease group and acute liver disease group in the amount of shunt by the nucleolide method.