Recently ultrasound and scintigraphic study are most useful modality for diagnosis of scrotal diseases. They are able to determine the nature, anatomic extent of the lesion, and possible to differential diagnosis of the scrotal lesion. The ultrasound and scintigraphie findings were analyses in 59 patients of ronfirmed scrotal disease at Seoul Red Cross Hospital from June 1986 to Aug. 1989. The results were as follows. 1) Miost patients were below the 30 years old age (69.4%), and most prevalent age was 11-30 Yrs. in trauma, 31-40 Yrs. in inflammation, and 51-60 Yrs. in mass lesion of scroturn. 2) The diagnostic accuracy of scrotal disease was 94.9% in ultrasound and 729 in scintigraphic study. The ultrasound study showed high accuracy in all kind of scrotal disease, but scintigraphy showed only high detection rate in inflamrnatory disease. 3) Scrotal ultrasound is first choice of study for the diagnosis of scrotal lesion, and useful determine the cystic or solid lesion and anatornic extent of disease. However it cant he differentiate the acute epididymitis with acute testicular torsion. 4) Scrotal scintigraphy is useful study for the diagnosis of acute painful scrotal disease, and showed specific findings in acute epididymitis and acute torsion for differential diagnosis. 5) In consideration of age, history and clinical findings of patient, appropriate study will be chosen firstly in ultrasound and scintigraphy, and combined ail of findings of these studies will be helpful for the accurate diagnosis and adequate treatment of scrotal disease.