원저 : 뇌혈류 평가용 99mTc - HMPAO 합성 및 분포에 관한 연구 ( A Study on Synthesis of 99mTc - HMPAO as A Brain Perfusion Agent and Its Distribution )
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이명철(Myung Chul Lee),이범우(Bum Woo Lee),정준기(June Key Chung),조보연(Bo Youn Cho),고창순(Chang Soon Koh),정재민(Jae Min Jeong),염미경(Mi Kyung Yeom),홍미경(Mee Kyoung Hong),최석례(Seok Rye Choi), |
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| Abstract |
HMPAO was synthesized by two step reaction. d, 1-HMPAO
was separated from the racemic product by fractional
recrystalization in ethylacetate, and the chemical
structure and purity was confirmed by proton NMR
spectroscopy. The synthesized d, 1-HMPAO was labeled
with Tc- 99m and studied the biodistribution in mice.
From the results we could find that liver uptake of
synthesized Tc-99m d, 1-HMPAO was higher than that of
Amersham kit, but no conspicuous difference was found
in brain and other tissues (blood, lung, stomach,
intestine, muscle, spleen and kidney). |
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| Full text Article |
28501049.pdf 
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