Author |
이명철(Myung Chul Lee),배상균(Sang Kyun Bae),이명혜(Myung Hae Lee),정준기(June Key Chung),고창순(Chang Soon Koh),노재규(Jae Kyu Roh),명호진(Ho Jin Myung), |
Abstract |
Regional cerebral blood flow were measured in 10
patients with Parkinson's disease and 12 normal persons
using Tc-99m-HMPAO SPECT. Reconstructed images were
interpreted qualitatively and were compared with those
findings of CT. For the quantitative analysis, six
pairs of region of interest matched with the perfusion
territories of large cerebral arteries and cerebellar
hemisphere were determined. From the count values,
indices showing the degree of asymmetry between right
and left cerebral or cerebellar hemisphere, cerebral
asymmetry index (ASI) and percent index of cerebellar
asymmetry (PIA), and an index showing change of each
region, region to cerebellum ratio (RCR) were obtained.
ASI of normal persons and patients were 0.082¡¾0.033
and 0.108¡¾0.062, respectively and PIA were
-0.4¡¾0.7% and -0.7¡¾1.0%, respectively, which
showed no statistically significant difference between
normal persons and patients. Among 10 RCR's, those of
both regions of basal ganglia and both regions of
anterior cerebral artery were significantly reduced. We
concluded that the most significant reduction of
regional cerebral blood flow in patients with
Parkinson's disease was observed in the regions of
basal ganglia and in the regions of anterior cerebral
artery, and the degree of change in hemispheric blood
flow was similar in both hemisphere. |