Gastic emptying scan in diabetic patients is widely used to assess the degree of motility disturbance and the symtoms such as nausea, vomiting, bloating, abdominal pain and early gastric fullness which we can't find anatomic lesion by fiberoscopic or barium study. In order to determine the relationship among diabetic gastropathy, neropathy, retinopathy and disease duration, gastric emptying scan using Tc-99m- tin colloid labeled scramble egg in hamburger was performed in 10 healty male controls and 50 diabetic patients which were subdivided to no neuropathy, peripheral neuropathy and autonomic neuropathy groups according to the degree of diabetic neuropathy and no retinopathy, background retinopathy and proliferative retinopathy groups according to the degree of diabetic retinopathy. After medication of cisapride for 2 weeks, we observed the presence of improvement of gastric motility in diabetics. The results were as following: 1) In controls, gastric emptying time (GET1/2) was 75¡¾13.6 min and 2 hour gastric retension rate(GRR2) was 32¡¾11.1%. 2) In diabetics, GET/2 was prolonged more than 2 hours and GRR2 was 58¡¾23.1%. According to degree of neuropathy, GET1/2 was prolonged more than 2 hours in all three groups and GRR2 was 54¡¾24.1% in no neuropathy group, 57¡¾24.3% in peripheral neuropathy group and 69¡¾24.6% in autanomic neuropathy group. According to degree of retinopathy, GET1/2 was 110¡¾23.4 min in no retinopathy group and prolonged more than 2 hours in other two groups and GRR2 was 45¡¾21.6% in no retinopathy group, 71¡¾19.7% in background retinopathy group and 73¡¾21.5% in proliferative retinopathy group. 3) After cisapride for 2 weeks, GET1/2 and GRR2 were improved as 90¡¾14.6 min and 40¡¾13.8% (initial GET1/2 and GRR2 were above 2 hours and 61¡¾15.4%). We can conclude from above findings that gastropathy in diabetic neuropathy suggesting main underlying factor in motility disorder. The degree of retinopathy and disease duration were correlated with severity of gastropathy in diabetics. From the results of gastric emptying scan, we can conclude that cisapride was useful drug for improving diabetic gastropathy and gastric emptying scan was valuable for assessing severity of diabetic gastropathy as non-invasive method.