원저 : Zipeprol 남용환자에서 뇌 단일광자방출 전산화단층촬영술의 임상적 의의 ( Clinical Significance of Brain SPECT in Zipeprol Abusers ) () |
Author |
조대옥(Dai Ok Cho),김재필(Jae Phil Kim),김덕윤(Deog Yoon Kim),양형인(Hyung In Yang),고은미(Eun Mi Koh),김광원(Kwang Won Kim),최영길(Young Kil Choi), |
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Affiliation |
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Abstract |
Drug abuse is widespread in worldwide and has been
associated with neurologic complication. Zipeprol is
one of drugs which been abused for psychological
satisfaction in some adolescents. This agent is non-
opioid antitussive agent, which is not legally
considered as being capable of creating dependence or
abuse liability at therapeutic serum levels. But it has
been reported that acute or chronic overdose create
neurologic complication such as convulsion as well as
dependence. Recently we experienced six zipeprol
abusers who admitted due to convulsion and variable
neurologic symptoms. The aim of our study was to
determine the role of Tc-99m- HMPAO brain SPECT in
those patients. EEG and brain CT showed no abnormal
finding, but brain SPECT showed focal or multiple
perfusion abnormalities in frontal, parietal, occipital
cortex, basal ganglia, thalamus and especially at
temporal cortex. These results suggest that brain SPECT
may be a useful diagnostic tool to evaluate the
cerebral dysfunction indused by zipeprol abuse. |
Keyword |
Brain SPECT, Zipeprol |
Full text Article |
28501274.pdf
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