Author |
김명선(Myung Seon Kim),정내인(Nae In Jeong),이재용(Jai Yong Lee),김종순(Chong Soon Kim),김종호(Chong Ho Kim),이명철(Myung Chul Lee),고창순(Chang Soon Koh),김희근(Hee Geun Kim),강덕원(Duck Won Kang),송명재(Myung Jae Song), |
Abstract |
Radioactive iodine has been widely used in patients
with thyroid cancer combined with surgical treatment.
However, due to individual variations in absorption and
excretion and uptake by tumor tissue of radioactive
iodine, there are differences in therapeutic effect and
adverse effects even if the same doses are
administrated. So this study compared the therapeutic
effect and radiation hazard by measuring internal
radiation dose. Of total 27 patients with well
differentiated thyroid cancer who had been
thyroidectomized, we administered radioactive iodine
100 mCi, 150 mCi, 200 mCi. According to BEL DOSIMETRY
PROTOCOL, beta and gamma ray dose were estimated from a
polt of the logarithrn of the percent of dose per liter
of whole blood versus day, and percent dose retained
versus day using semilogarithmic paper, respectivel y.
1) Physical dose to whole blood averaged 56.54+13.02
rad in 100 mCi administered group, 76.83+ 19.97 rad in
150 mCi administered group, 95.08 +- 25.51 rad in 200
mCi administered group and there has been a significant
correlation among the groups. 2) Mean percent dose
retained 48 hours later was 26.34%. 3) There was no
significant correlation of physical dose between
absence and presence of metastasis. 4) l7 of 19
patients who has been followed up with TSH and serum
throglobulin, Thallium scan were successfully ablated
by radioactive iodine. 5) Leukocyte, lymphocyte,
neutrophil, platelet counts all declined in 4-6 weeks
and most of all were restored 3 months 1ater. 6) There
was no significant correlation between physical
dosimetry and biologic dosimetry. Generally
administered doses of radioactive iodine (100-200 mCi)
to patients with thyroid cancer postoperatively had
developed transient bone marrow suppression and minimal
chromosomal aberration, but they were within safety
dose to blood (200 rad). And there has been no
significant differences in residual dose 48 hours later
between Korean and western people. |