원저 : 실험 개에서 Rb - 82 심근 Dynamic PET 영상을 이용한 국소 심근 혈류 예측의 기본 모델 연구 ( A Study on the Estimation of Regional Myocardial Blood Flow in Experimental Canine Model with Coronary thrombosis using Rb - 82 Dynamic Myocardial Positron Em () |
Author |
곽철은(Cheol Eun Kwark),이동수(Dong Soo Lee),강건욱(Keon Wook Kang),황은경(Eun Kyung Hwang),정재민(Jae Min Jeong),장기현(Kee Hyun Chang),정준기(June Key Chung),이명철(Myung Chul Lee),서정돈(Joung Don Seo),고창순(Chang Soon Koh), |
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Affiliation |
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Abstract |
This study investigates a simple mathematical model for
the quantitative estimation of regional myocardial
blood flow in experimental canine coronary artery
thrombosis using Rb-82 dynamic myocardial positron
emission tomography. The coronary thrombosis was
induced using the new catheter technique by narrowing
the lumen of coronary vessel gradually, which finally
led to partial obstruction of coronary artery. Ten Rb-
82 dynamic myocardial PET scans were performed
sequentially for each experiment using our 5, 10% and
20 second acquisition protocol, respectively, and three
regions of interest were drawn on the transaxial
slices, one on left ventricular chamber for input
function and the other two on normal and decreased
perfusion segments for the flow estimation in those
regions. Single compartment model has been applied to
the measured sets of regional PET data, and the rate
constants of influx to myocardial tissue were
calculated for regional myocardia1 flow estimates with
the three parameter fits of raw data by the Levenberg-
Marquardt method. The results showed that, (1) single
compartment model suggested by Kety-Schmidt could be
used for the simple estimation of regional myocardial
blood flow, (2) the calculated regional myocardial
blood flow estimates were dependent on the selection of
input function, which reflected partial volume effect
and left ventricular wall motion, and (3)
mathematically fitted input and tissue time activity
curves were more suit-able than the direct application
of the measured data in terms of convergence. |
Keyword |
Rb-82 dynamic myocardial PET, Regional myocardial blood flow, Single compartment rnodel, Convergence |
Full text Article |
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