Abstract |
Purpose: We analysed Tc-99m-MAG3 renal scans to
evaluate renal function of transplanted kidney and to
detect various renal transplant complications,
measuring the ratio of renal radioactivity at three
minutes to that at 20 minutes(elimination index).
Material and Methods: The fifty seven renal
transplantation recipients were studied. There were 50
normal functioning transplanted kidneys as group I and
7 abnormal functioning transplanted kidney, including 5
cases of acute renal rejection, 2 Gases of acute
tubular necrosis as group II. The protocol consisted
of: (1) Tc-99m-MAG3 740MBq injection intravenously; (2)
sequential imaging for 2min(60two-second images)
followed by 30min(30 sixty-second images); (3) drawing
of region of interest(ROI) on renal imaging; (4) time-
activity curves were generated from renal ROI after
background subtra ction, and time of maximum
activity(Tmax) and half time of maximal peak
radioactivity(T1/2) were produced in the renogram
curve. (5) EI through Bischof-delaoye method as
determined on the renogram curve. Results: Normal
group(I) shows mean EI of 2.21(95.0% Confidence limit
of 2.01-2.87), Tmax, of 154 sec, t1/2 of 1,139 sec.
Abnormal group(II) shows mean EI of 0.74, Tmax of 1,466
sec, t1/2 of 19,224 sec. The EI, Tmax, T1/2, BUN and
serum creatinine values are significantly different
between normal group(I) and abnormal group(II) (p
〈0.0001). Conclusion: By measuring EI-with Tc-99m-
MAG3, renal function of transplanted kidney could be
easily evaluated and various complications could be
detected early. |