원저 : 방사성옥소 투여에 따른 말초혈액 림프구 수의 변화 및 염색체이상 빈도의 관찰 ( Observation on the Frequency of Chromosomal Aberration and Changes in Number of Peripheral Lymphocytes in Radioactive Iodine Treatment ) () |
Author |
구천희(Chun Hee Koo),신민호(Min Ho Shin),박영주(Young Ju Park),이정임(Jung Yim Lee),박태용(Tae Yong Park),이재용(Jae Yong Lee),김종순(Chong Soon Kim),한승수(Seung Soo Han),김광회(Kwang Hoe Kim),김희근(Hee Geun Kim),강덕원(Duck Won Kang),송명재(Myung Jae Song), |
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Affiliation |
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Abstract |
Background: For biological dosimetry of radiation
exposure, both observing hema-tologic change and
calculating Ydr by chromgsomal analysis as biological
indicators are widely used. However, due to the lack of
studies on biological dosimetry of radiation dose
absorbed in the body such as in the cases of
radioactive iodine therapy, the maximal and safe dose
is not well known, nor is the extent to which the body
can safely endure radiation exposure. Purpose: To
investegate the practical applicability of hematologic
changes and Ydr as an indicator for estimating
radiation exposure, to patients with thyroid diseases
after doses of radioactive iodine. Material and
Methods: 5 patients with hyperthyroidism and 35
patients who have had thyroid cancer operation were
under treatment with radioactive iodine, changes in
number of lymphocytes were tracked and Ydr was
calculated for more than 2 months by chromosomal
analysis in peripheral lymphocytes. Results: 1) The
number of lymphocytes began to decrease 2 weeks after
doses of radioactive iodine, and reached the nadir
after 6 and 8 weeks, then gradually recovered. 2) The
nadir count of lymphocytes was reversely correlated
with the administered dosage of radioactive iodine. 3)
Ydr was generally stable between 2 and 8 weeks. 4) The
maximal value of Ydr was correlated with the
administered dosage of radioactive iodine. 5) Ydr value
at the 2nd week increased with augmented dosage of
radioactive iodine. 6) Ydr value at the 2nd week was
correlated with fall of lymphocyte count. Conclusion:
Patients must be closely observed, because temporary
bone marrow suppression and slight chromosomal
aberration can be produced by even generally used
dosages of radioactive iodine for diagnosis and
therapy. Maximal percent fall of lymphocyte count, Ydr
at the 2 week interval and maximal Ydr can be used as
the biological predictor of administered dosage of
radioactive iodine. |
Keyword |
Thyroid cancer, Hypeithyroidism: Radioactive iodine treatment; Lyrnphocyte conunt Chromosomal aberration |
Full text Article |
28501546.pdf
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