원저 : I-123 표지 지방산의 체내 분포 및 대사 ( I ) - < I-123 > 15-( p-iodophenyl ) pentadecanoic acid ( IPPA ) ( Biodistribution and Metabolism of I-123 Labelled Fatty Acid ( I ) - < I-123 > 15-( p-iodophenyl ) pentadecanoic acid ( IPPA ) ) () |
Author |
장영수(Young Soo Chang),이동수(Dong Soo Lee),정재민(Jae Min Jeong),서용섭(Yong Sup Suh),정준기(June Key Chung),이명철(Myung Chul Lee),고창순(Chang Soon Koh), |
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Affiliation |
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Abstract |
I-123 labelled fatty acids are suitable for
investigation of regional myocardial metabolism, so
they are on the clinical trial. However, the precise
properties of these materials are not characterized
yet. We have synthesized phenylpentadecanoic acid and
labeled this compound with I-123. The purpose of this
study was to examine the stability, biodistribution,
metabolism and SPECT imaging of [I-123]15-(p-
iodophenyl)pentadecanoic acid(I-123-IPPA) that we made.
The stability test of I-123-IPPA in serum of rat, mouse
and human showed no free I-123 after 1 hour. In
biodistribution study in mice for various time
intervals after injection(5, 10, 15, 30, 60 minutes),
uptake in myocardium was 14.5%ID/g(5 min), and
1.9%ID/heart(5 min), while uptake in muscles was
2.6%ID/g(5 min). Myocardium to blood ratio and
myocardium to lung ratio increased for 5 min after
injection and then decreased rapidly. Chromatographic
data of rat blood and urine showed that little PPA was
found in blood and urine 15-20 min after injection. The
myocardial I-123-IPPA SPECT images of a dog with
myocardial infarction showed defects similar to those
of Tc-99m-MIBI and F-18-FDG. These data suggest that I-
123-IPPA is quite stable in vitro and shows favorable
biodistribution in mice. SPECT imaging with I-123-IPPA
demonstrated infarct zone as photon defect in dog model
of myocardial infarction. I-123-IPPA may be used for
the evaluation of fatty acid metabolism in clinical
trials in Korea. |
Keyword |
I-123-IPPA, Biodistribution, dynamic SPECT |
Full text Article |
28502117.pdf
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