원저 : 생쥐 종양모델에서 57Co-Vitamin B12의 종양 친화성에 관한 연구 ( Affinity for 57Co-Vitamin B12 by a Wide Histologic Variety of Tumor Types in Mice ) () |
Author |
손명희(Myung Hee Sohn),박순아(Soon A Park),김수현(Su Hyun Kim),정경호(Gyung Ho Chung),임창열(Chang Yeol Yim), |
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Affiliation |
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Abstract |
The search for tumor-avid agents for use in nuclear
medicine imaging is an ongoing field of importance. The
purpose of this study was to determine the affinity for
radiolabeled vitamin B12 by a wide histologic variety
of tumor types in mice. Seventeen different types of
tumor were grown subcutaneously in female Balb/C or
Balb nu/nu(nude) mice. When the tumors reached about 1
cm in diameter, mice were injected intraperitoneally
with 57Co-vitamin B12. Twenty-foul hours later, the
mice were sacrificed. Organs and tissues were removed,
weighed, and activity per mg determined by gamma
counter. Values represented cpm/mg tissue that was
normalized to 20 grams body weight for each mouse. A
wide variety of tumor types showed significant uptake
and concentration of 57Co-vitamin B12, as evidenced by
tumor:tissue activity ratios. For many tissues of great
importance in terms of background(bone, muscle, blood),
the tumor:tissue activity ratios of uptake were high.
These data strongly suggest that further efforts to
evaluate the utility of radiolabeled adducts of vitamin
B12 for clinical use in oncologic imaging are
warranted. |
Keyword |
57Co, Vitamin B12, Tumor, Mice |
Full text Article |
28502121.pdf
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