혈관성형술 후 재협착 방지 치료에 사용하기 위한 원통형 풍선 Re-188-DTPA 의 선량 분포와 내부피폭 선량 ( Dosimetry and Medical Internal Radiation Dose of Re-188-DTPA for Endovascular Balloon Brachytherapy Against Restenosis after Coronary Angioplasty ) () |
Author |
이진(Jin Lee),이동수(Dong Soo Lee),신승애(Seung Ae Shin),정재민(Jae Min Jeong),정준기(June Key Chung),이명철(Myung Chul Lee), |
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Affiliation |
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Abstract |
Purpose: Liquid beta emitter filled in angioplasty
balloon could be used to perform endovascular balloon
brachytherapy to prevent coronary artery restenosis. We
investigated the dosimetry for Re-188-DTPA liquid-
filled balloon and medical internal radiation dosimetry
in case of balloon leakage. Materials and Methods: We
estimated radiation dose from an angioplasty balloon
(20 mm lengfh, 3 mm diameter cylinder) to the adjacent
vessel wall using Monte Carlo EGS4 code. We obtained
time-activity curves of kidneys in normal dog and
calculated Tmax, T1/2. Using MIRDOSE3 program, we
estimated absorbed doses to the major organs (kidneys,
bladder) and the whole body when we assumed that
balloon leaked all the isotope contained. Results: The
radiation dose was 17.5 Gy at the balloon surface when
we applied 3,700 MBq/ml of Re-188 for 100 seconds.
Fifty percent of the energy deposited within 1 mm from
the balloon surface. The estimated internal dose to the
whole body was 0.005 mGy/MBq and 18.5 mGy for the
spillage of 3,700 MBq of Re-188. Conclusion: We suggest
that Re-188-DTPA can be used for endovascular balloon
brachytherapy to inhibit coronary artery restenosis
after angioplasty with tolerable whole body radiation
dose in case of balloon rupture. |
Keyword |
Re-188-DTPA, dosimetry, MIRD, restenosis |
Full text Article |
28501981.pdf
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