제21차 대한핵의학회 연수교육 : 핵의학치료 / 관동맥혈관 내 방사선 근접 치료 ( Intracoronary Radiation Therapy ) () |
Author |
문대혁(Dae Hyuk Moon),박성욱(Seong Wook Park),홍명기(Myeong Ki Hong),오승준(Seung Jun Oh),범희승(Hee Seung Bom),이희경(Hee Kyung Lee), |
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Affiliation |
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Abstract |
Restenosis remains a major limitation of percutaneous
coronary interventions. Numerous studies including
pharmacological approaches and new devices failed to
reduce the restenosis rate except coronary stenting.
Since the results of BENESTENT1) and STRESS2) studies
came out, coronary stenting has been the most popular
interventional strategy in the various kinds of
coronary stenotic lesions, although the efficacy of
stenting was shown only in the discrete lesion of the
large coronary artery. The widespread use of coronary
stenting has improved the early and late outcomes after
coronary intervention, but it has also led to a new and
serious problem, e.g., in-stent restenosis.
Intravascular radiation for prevention of restenosis is
a new technology in the field of percutaneous coronary
intervention. Recent animal experiments and human
trials have demonstrated that local irradiation, in
conjunction with coronary interventions, substantially
diminished the rate of restenosis. This paper reviews
basic radiation biology of intracoronary radiation and
its role in the inhibition of restenosis. The current
status of intracoronary radiation therapy using Re-188
liquid balloon is also discussed. |
Keyword |
Intracoronary radiation therapy, Restenosis, Re-188 |
Full text Article |
28503322.pdf
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