심장핵의학 분자영상학 (Molecular Nuclear Cardiac Imaging) |
Author |
이동수,팽진철, |
Dong Soo Lee, M..D. Ph.D., Jin Chul Paeng, M..D. |
Affiliation |
서울대학교 의과대학 핵의학교실 Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea |
Abstract |
Molecular nuclear cardiac imaging has included Tc-99m Annexin imaging to visualize myocardial apoptosis, but is
now usually associated with gene therapy and cell-based therapy. Cardiac gene therapy was not successful so far
but cardiac reporter gene imaging was made possible using HSV-TK (herpes simplex virus thymidine kinase) and
F-18 FHBG (fluoro-hydroxymethylbutyl guanine) or I-124 FIAU (fluoro-deoxyiodo-arabino-furanosyluracil). Gene delivery
was performed by needle injection with or without catheter guidance. TK expression did not last longer than 2
weeks in myocardium. Cell-based therapy of ischemic heart or failing heart looks promising, but biodistribution
and differentiation of transplanted cells are not known. Reporter genes can be transfected to the stem/progenitor
cells and cells containing these genes can be transplanted to the recipients using catheter-based purging or
injection. Repeated imaging should be available and if promoter are varied to let express reporter transgenes,
cellular (trans)differentiation can be studied. NIS (sodium iodide symporter) or D2R receptor genes are promising in this aspect. (Korean J Nucl Med 38(2):175-179, 2004) |
Keyword |
Molecular imaging, Nuclear cardiology, Reporter gene, Cell-based therapy, Gene therapy |
Full text Article |
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