세포고사의 핵의학영상 (In Vivo Nuclear Imaging of Apoptosis) |
Author |
이태섭,천기정, |
Tae Sup Lee, Ph.D. and Gi Jeong Cheon, M.D. |
Affiliation |
원자력의학원 싸이클로트론응용연구실, 핵의학과 1Laboratory of Cyclotron Application and 2Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences, Seoul, Korea |
Abstract |
Apoptosis plays a role in the pathophysiology of many kinds of diseases and in the response of treatment.
Compared to the necrosis, the apoptosis is a genetically controlled and energy-dependent process which removes
the unwanted cells from the body; programmed cell death or cell suicide. During the apoptosis, phosphatidylserine
is expressed in the cytoplasmic outer membrane in the early phase. Annexin V, an endogenous human protein
(MW=35 kD), has an affinity of about 10-9 M for the phosphatidylserine exposed on the outer membrane of
apoptotic cells. Annexin V can be radiolabeled with 99mTc by HYNIC or EC chelators, which can be used as an
radiotracer for the in vivo imaging of apoptosis. In this article, we reviewed the apoptosis, radiolabeling of annexin V, and the experimental and clinical data using annexin V imaging.(Korean J Nucl Med 38(2):190-197, 2004) |
Keyword |
Aapoptosis, 99mTc-annexin V |
Full text Article |
3802190.pdf
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