한국인 뇌 표준판과 해부학적 및 세포구축학적 확률뇌지도를 이용한 뇌영상 정량화 (Quantification of Brain Images Using Korean Standard Templates and Structural and Cytoarchitectonic Probabilistic Maps) |
Author |
이재성1,이동수1,김유경1,김진수1,이종민2,구방본2,김재진3,권준수4,유태우5,장기현6김선일2,강혜진1,강은주1,정준기1,이명철1, |
Jae Sung Lee, Ph.D.1, Dong Soo Lee, M.D.1, Yu Kyeong Kim, M.D.1, Jin Su Kim, M.S.1, Jong Min Lee, Ph.D.2,Bang Bon Koo, M.S.2, Jae-Jin Kim, M.D.3, Jun Soo Kwon, M.D.4, Tae Woo Yoo, M.D.5, Ki Hyun Chang, M.D.6,Sun I. Kim, Ph.D.2, Hyejin Kang, M.S.1, Eunjoo |
Affiliation |
서울의대 핵의학교실1, 신경정신과학 교실4, 가정의학교실5, 방사선과학교실6, 한양대 의공학과2, 연세대 신경정신과 Departments of Nuclear Medicine1, Neuropsychiatry4, Family Medicine5, and Diagnostic Radiology6,Seoul National University, Department of Biomedical Engineering, Hanyang University2,Department of Neuropsychiatry, Yonsei University3, Seoul, Korea |
Abstract |
Purpose: Population based structural and functional maps of the brain provide effective tools for the analysis and
interpretation of complex and individually variable brain data. Brain MRI and PET standard templates and statistical
probabilistic maps based on image data of Korean normal volunteers have been developed and probabilistic maps
based on cytoarchitectonic data have been introduced. A quantification method using these data was developed
for the objective assessment of regional intensity in the brain images. Materials and Methods: Age, gender and
ethnic specific anatomical and functional brain templates based on MR and PET images of Korean normal
volunteers were developed. Korean structural probabilistic maps for 89 brain regions and cytoarchitectonic
probabilistic maps for 13 Brodmann areas were transformed onto the standard templates. Brain FDG PET and SPGR
MR images of normal volunteers were spatially normalized onto the template of each modality and gender.
Regional uptake of radiotracers in PET and gray matter concentration in MR images were then quantified by
averaging (or summing) regional intensities weighted using the probabilistic maps of brain regions. Regionally
specific effects of aging on glucose metabolism in cingulate cortex were also examined. Results: Quantification
program could generate quantification results for single spatially normalized images per 20 seconds. Glucose
metabolism change in cingulate gyrus was regionally specific: ratios of glucose metabolism in the rostral anterior
cingulate vs. posterior cingulate and the caudal anterior cingulate vs. posterior cingulate were significantly
decreased as the age increased. ‘Rostral anterior’/ ‘posterior’ was decreased by 3.1% per decade of age (P<10-11,
r=0.81) and ‘caudal anterior’/ ‘posterior’ was decreased by 1.7% (P<10-8, r=0.72). Conclusion: Ethnic specific
standard templates and probabilistic maps and quantification program developed in this study will be useful for
the analysis of brain image of Korean people since the difference in shape of the hemispheres and the sulcal
pattern of brain relative to age, gender, races, and diseases cannot be fully overcome by the nonlinear spatial
normalization techniques. (Korean J Nucl Med 38(3):241-252, 2004) |
Keyword |
Statistical probabilistic map, Standard template, PET, SPECT, Quantification |
Full text Article |
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