유방암 환자에서 근치적 유방 절제술 후 재발 발견에 대한 CA 15-3의 역할 (The Role Of Tumor Marker CA 15-3 In Detection of Breast Cancer Relapse After Curative Mastectomy) |
Author |
현인영.김인호1.이문희1.김철수1, |
In Young Hyun, M.D., In Ho Kim, M.D.1, Moon Hee Lee, M.D.1, Chul Soo Kim, M.D.1 |
Affiliation |
인하대학교 병원, 핵의학과, 혈액종양 내과1 Department of Nuclear Medicine and Internal Medicine,1 Inha University College of Medicine, Inchon, Korea |
Abstract |
Purpose: The purpose of this study was to determine the utility of tumor marker CA 15-3 in the following: the
diagnosis of breast cancer relapse after curative mastectomy, and the differentiation of the value of tumor marker
by site of metastases. Materials and Methods: Two hundred two patients (median age 48 years) with breast
cancer included in the follow-up after curative mastectomy. The tumor marker CA 15-3 was determined by IRMA
(CIS BIO INTERNATIONAL, France). Test values > 30 U/ml were considered elevated (positive). Results: Among 202
patients, recurrent diseases were found in 16 patients. CA 15-3 was elevated in 5 of 16 patients with recurrences.
There was no false-positive patient who had elevated CA 15-3. Sensitivity and specificity of CA 15-3 for detection
of breast cancer recurrence were 31%, and 100%. CA 15-3 was elevated in all of the 4 patients with liver
metastases. CA 15-3 was elevated in none of the patients who relapsed with metastasis to bone-only or
contralateral breast-only. Conclusion: The tumor marker CA 15-3 in the detection of breast cancer relapse after
curative mastectomy is specific, but not sensitive. However, it is useful to rule out liver metastases of breast
cancer, which indicates bad prognosis. (Korean J Nucl Med 38(4):311-317, 2004) |
Keyword |
breast cancer, CA 15-3, follow-up, relapse, tumor marker |
Full text Article |
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