심근 저산소증 영상 (Imaging Hypoxic Myocardium) |
Author |
배상균, |
Sang Kyun Bae, M.D. |
Affiliation |
인제대학교 의과대학 핵의학교실 Department of Nuclear Medicine, Inje University College of Medicine, Busan, Korea |
Abstract |
Hypoxia (decreased tissue oxygen tension) is a component of many diseases such as tumors, cerebrovascular
diseases and ischemic heart diseases. Although hypoxia can be secondary to a low inspired pO2 or a variety of
lung disorders, the most common cause is ischemia due to an oxygen demand greater than the local oxygen
supply. In the heart tissue, hypoxia is often observed in persistent low-flow states, such as hibernating
myocardium.
Direct “hot spot” imaging of myocardial tissue hypoxia is potentially of great clinical importance because it may
provide a means of identifying dysfunctional chronically ischemic but viable hibernating myocardium. A series of
radiopharmaceuticals that incorporate nitroimidazole moieties have been synthesized to detect decreased local
tissue pO2. In contrast to agents that localize in proportion to perfusion, these agents concentrate in hypoxic
tissue. However, the ideal agents are not developed yet and the progress is very slow. Furthermore, the research
focus is on tumor hypoxia nowadays. This review introduces the myocardial hypoxia imaging with summarizing
the development of radiopharmaceuticals.(Korean J Nucl Med 39(2):141-145, 2005) |
Keyword |
hypoxia, nitroimidazole, hibernating myocardium |
Full text Article |
39020141.pdf
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