두경부암 경부 림프절 전이의 진단에서 18F-FDG-PET/CT의 유용성 (Usefulness of 18F-FDG PET/CT in the Diagnosis of Cervical Lymph Node Metastases of Head and Neck Cancer) |
Author |
김정호,김성훈,오주현,유이령,정용안,박영하,손형선,이성용,정수교, |
Chung Ho Kim M.D., Sung Hoon Kim M.D., O Joo-Hyun M.D., Ie Ryung Yoo M.D.,Soo Kyo Chung M.D. |
Affiliation |
가톨릭대학교 의과대학 방사선과학교실 Department of Radiology, College of Medicine, Catholic University of Korea, Seoul, Korea |
Abstract |
Purpose: This study evaluated the diagnostic value of 18F-FDG PET/CT in detecting cervical lymph node
metastases in head and neck cancer patients. Materials & Methods: The patients were divided into two groups,
46 patients underwent PET/CT scan for initial staging before surgery, and 20 patients for restaging of recurrence
after primary treatment. Increased FDG uptakes in cervical lymph nodes were evaluated retrospectively and
correlated with the histopathologic results. Results: In the initial staging group, 21 lymph nodes were detected by
PET/CT in 15 patients. 20 lymph nodes were confirmed as metastases with a mean peak SUV of 5.84, and the
remaining one lymph node was an inflammatory lesion, with a peak SUV of 2.75. Seven metastatic lymph nodes
were reported only by histopathology. The sensitivity, specificity, positive predictive value and negative predictive
value were 74.0%, 99.6%, 95.2% and 97.3%, respectively. In the recurrence group, 11 lymph nodes were detected
in 9 patients, and 8 nodes were true positive, with a mean peak SUV of 5.65. The other three were inflammatous
lymph nodes, and the peak SUVs were 2.16, 2.94 and 3.53. One false negative lymph node was reported. The
sensitivity, specificity, positive predictive value and negative predictive value were 88.8%, 97.7%, 72.7% and 92.9%,
respectively. Conclusions: FDG-PET/CT shows higher positive predictive value in the initial staging group, and
better sensitivity in the recurrence group. Therefore PET/CT could be useful for both initial staging and restaging of recurrent cervical lymph node metastases.(Korean J Nucl Med 39(5):269-277, 2005) |
Keyword |
Head and neck cancer, F-18-FDG PET/CT, Cervical lymph node metastasis |
Full text Article |
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