사구체여과율 계산을 위한 99mTc-DTPA를 이용한 다중 채혈 이중지수법의 적정 채혈 횟수 및 시간의 선정 (Determination of Appropriate Sampling Frequency and Time of Multiple Blood Sampling Dual Exponential Method with 99mTc-DTPA) |
Author |
김정호1,오주현1,정용안1,유이령1,손형선1,김성훈1,정수교1,이형구2, |
Chung Ho Kim, M.D.1, O Joo-Hyun, M.D.1, Yong An Chung, M.D.1, Ie Ryung Yoo, M.D.1, Hyung Sun Sohn, M.D.1, Sung Hoon Kim, M.D.1, Soo Kyo Chung, M.D.1, and Hyoung Koo Lee, Ph.D.2 |
Affiliation |
가톨릭대학교 의과대학 방사선과학교실1, 의공학교실2 Departments of 1Radiology and 2Biomedial Engineering, College of Medicine, Catholic University of Korea, Seoul, |
Abstract |
Purpose: To determine appropriate sampling frequency and time of multiple blood sampling dual exponential
method with 99mTc-DTPA for calculating glomerular filtration rate (GFR). Materials & Methods: Thirty four patients
were included in this study. Three mCi of 99mTc-DTPA was intravenously injected and blood sampling at 9 different
times, 5ml each, were done. Using the radioactivity of serum, measured by gamma counter, the GFR was
calculated using dual exponential method and corrected with the body surface area. Using spontaneously chosen
2 data points of serum radioactivity, 15 collections of 2-sample GFR were calculated. And 10 collections of
3-sample GFR and 12 collections of 4-sample GFR were also calculated. Using the 9-sample GFR as a reference
value, degree of agreement was analyzed with Kendall's τcorrelation coefficients, mean difference and standard
deviation. Results: Although some of the 2-sample GFR showed high correlation coefficient, over or
underestimation had evolved as the renal function change. The 10-120-240 min 3-sample GFR showed a high
correlation coefficient (τ=0.93), minimal difference (Mean±SD=-1.784±3.972), and no over or underestimation as
the renal function changed. The 4-sample GFR showed no better accuracy than the 3-sample GFR. Conclusions:
In the wide spectrum of renal function, the 10-120-240 min 3-sample GFR could be the best choice for estimating
the patients' renal function. (Nucl Med Mol Imaging 2006;40(1):33-39) |
Keyword |
99mTc-DTPA, Glomerular filtration rate, Multiple blood sampling technique, Two-compartment model |
Full text Article |
40010233.pdf
|
|
|