대장-직장암의 간전이에서 FDG PET과 MR의 진단 성능 (Diagnostic Accuracy of PET and MR for Detecting Liver Metastasis from Colorectal Cancer) |
Author |
박은경,강원준,어재선,이동수,정준기,이명철, |
Eun Kyung Park, M.D., Won Jun Kang, M.D., Jae Seon Eo, M.D., Dong Soo Lee, M.D., Ph.D., June-Key Chung, M.D., Ph.D. and Myung Chul Lee, M.D., Ph.D. |
Affiliation |
서울대학교 의과대학 핵의학교실 Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea |
Abstract |
Purpose: Although computed tomography (CT) is widely used for diagnosing liver metastasis from colorectal
cancer, diagnostic accuracy of CT is not satisfactory. Magnetic resonance (MR) imaging and F-18 FDG PET has
been reported to be superior to CT. However, studies on direct comparison of PET and MR are scarce. We
compared the diagnostic accuracy of FDG PET and MR in detecting liver metastasis from colorectal cancer.
Materials and Methods: Among 363 colorectcal cancer patients who underwent F-18 FDG PET (ECAT,
Siemens-CTI, Knoxville; Gemini, Philips, Milpitas, U.S.), 26 patients (M:F=17:9, age=62¡¾11) underwent MR to
evaluate suspicious metastatic liver lesions. Finally, 35 liver lesions detected by CT from 26 patients were enrolled
for analysis. PET and MR results were compared with pathologic reports, clinical findings or follow-up results.
Results: Of the 35 lesions, 18 lesions (51.4%) were diagnosed as liver metastases, while remaining 17 (48.6%) as
benign. The sensitivity and the specificity of PET were 94.4% and 94.1%, respectively, compared to 100% and
82.4% for MR. MR and PET was concordant in 30 lesions (85.7%): 17 metastatic (94.4%) and 13 benign (76.5%)
lesions. ROC curve analysis revealed maximal SUV of 3.1 as the optimum standard in differentiating metastatic
from benign liver lesions (AUC=0.897, p<0.001, sensitivity 83.3%, specificity 94.1%). For small lesions less than 1cm
in diameter (n=20), diagnostic accuracy of PET was comparable to that of MR. Conclusion: F-18 FDG PET
showed good diagnostic performance in detecting liver metastasis from colorectal cancer, which was comparable
to MR. (Nucl Med Mol Imaging 2006;40(5):249-256)
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Keyword |
fluorodeoxyglucose, positron emission tomography, colon cancer, liver metastasis, magnetic resonance |
Full text Article |
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