원저 : 11C-Acetate와 3차원 PET/CT를 이용한 심근의 산소 소모량 평가: 재순환 교정법 및 수정 단일구획 추적자 동적 모델 적용 (Evaluation of Myocardial Oxygen Consumption with 11C-Acetate and 3D PET/CT: By Applying Recirculation Correction Method and Modified One-Compartmental Tracer Kinetic Modeling) |
Author |
천인국, 황경훈1, 이상윤2, 김진수3, 이재성4, 신희원5, 이민경1, 윤민기1, 최원식1, |
In-Kook Chun, BSc, Kyung-Hoon Hwang, MD, PhD1, Sang-Yoon Lee, PhD2, Jin-Su Kim, PhD3, Jae Sung Lee, PhD4, Hee-Won Shin5, Min-Kyung Lee, M.D.1, Minki Yoon, M.D.1, Wonsick Choe, MD, MPH1 |
Affiliation |
가천의과학대학교 의학전문대학원, 가천의과학대학교 길병원 핵의학과1, 가천의과학대학교 뇌과학연구소2, 한국원자력의학원 분자영상 연구부3, 서울대학교 의과대학 핵의학교실4, 지멘스 메디컬 솔루션5 School of Medicine, Gachon University of Medicine and Science, Incheon, Korea 1 Department of Nuclear Medicine, Gachon University of Medicine and Science, Incheon, Korea 2Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, |
Abstract |
Purpose: We intended to evaluate myocardial oxygen consumption (MVO2) by applying recirculation correction and modified one-compartment model to have a reference range of MVO2 in normal young population and to reveal the effect of recirculation on time-activity curve (TAC).
Materials and Methods: In nine normal male volunteers with mean age of 26.3±4.0, MVO2 was estimated with 925 MBq (25mCi) of 11C-Acetate (Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, Korea) and PET/CT (Biograph 6, Siemens Medical Solution, Germany). Analysis software such as MATLAB? v7.1 (Mathworks, Inc., United States), Excel? 2007 (Microsoft, United States), and SPSS? v12.0 (Apache Software Foundation, United States) were used. Twenty three frames were of 12×10, 5×60, 3×120, 2×300's duration, respectively. The modified one-compartmental model and the recirculation correction method were applied. Statistical analysis was performed by using Test of Normality, ANOVA and Post-Hoc (Scheffe’s) analysis, and p-value less than 0.05 was considered as significant.
Results: The normal reference ranges of MVO2 were presented as 3.18-4.64 ×10-4 ml/g/sec, 1.91-3.94 ×10-4 ml/g/sec, 4.31-6.40 ×10-4 ml/g/sec, 2.84-4.53 ×10-4 ml/g/sec and 3.42-5.00 ×10-4 ml/g/sec in the septum, the inferior wall, the lateral wall, the anterior wall and the entire wall, respectively. In addition, it was noted that the dual exponentiality of the clearance curve is due to the recirculation effect and that the characteristic of the curve is essentially mono-exponential.
Conclusion: 11C-Acetate is a radiotracer worthwhile to assess MVO2. Re-circulated 11C can influence TAC of 11C in myocadia and so the recirculation correction must be considered when measuring MVO2. |
Keyword |
carbon-11 acetate, positron emission tomography, computed tomography, recirculation, one- compartmental model |
Full text Article |
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