갈색세포종의 초기 진단에서 I-123/I-131 Metaiodobenzylguanidine 스캔의 단일 검사로써의 진단 성능: 생화학적 검사, 해부학적 영상과 비교 (Efficacy of I-123/I-131 Metaiodobenzylguanidine Scan as A Single Initial Diagnostic Modality in Pheochromocytoma: Comparison with Biochemical Test and Anatomic Imaging) |
Author |
문은하1, 임석태1,2,3, 정영진1,3, 김동욱1,2,3, 정환정1,2,3, 손명희1,2,3, |
un-Ha Moon, M.D.1, Seok Tae Lim, M.D.1,2,3, Young Jin Jeong, M.D.1,2, Dong Wook Kim, Ph.D.1,2,3, Hwan-Jeong Jeong, M.D.1,2,3, and Myung-Hee Sohn, M.D.1,2,3 |
Affiliation |
전북대학교 의학전문대학원 핵의학교실1, 임상의학연구소2, 사이클로트론연구소3 1Department of Nuclear Medicine, 2Research Institute of Clinical Medicine, and 3Cyclotron Research Center, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk, Korea |
Abstract |
Purpose: We underwent this study to evaluate the diagnostic potential of I-123/I-131 metaiodobenzylguanidine (MIBG) scintigraphy alone in the initial diagnosis of pheochromocytoma, compared with biochemical test and anatomic imaging. Materials & Methods: Twenty two patients (M:F=13:9, Age: 44.3¡¾ 19.3 years) having the clinical evaluation due to suspicious pheochromocytoma received the biochemical test, anatomic imaging modality (CT and/or MRI) and I-123/I-131 MIBG scan for diagnosis of pheochromocytoma, prior to histopathological confirmation. MIBG scans were independently reviewed by 2 nuclear medicine physicians. Results: All patients were confirmed histopathologically by operation or biopsy (incisional or excisonal). In comparison of final diagnosis and findings of each diagnostic modality, the sensitivities of the biochemical test, anatomic imaging, and MIBG scan were 88.9%, 55.6%, and 88.9%, respectively. And the specificities of the biochemical test, anatomic imaging, and MIBG scan also were 69.2%, 69.2%, and 92.3%, respectively. MIBG scan showed one false positive (neuroblastoma) and one false negative finding. There was one patient with positive MIBG scan and negative findings of the biochemical test, anatomic imaging. Conclusion: vOur data suggest that I-123/I-131 MIBG scan has higher sensitivity, specificity, positive predictive value, negative predictive value and accuracy than those of biochemical test and anatomic imaging. Thus, we expect that MIBG scan is e tectively used for initial diagnosis of pheochromocytoma alone as well as biochemical test and anatomic imaging. |
Keyword |
Pheochoromocytoma, MIBG, biochemical test, anatomic imaging |
Full text Article |
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